ABSTRACT
Studies have provided strong evidence for the importance of primary or secondary inflammatory processes in the pathogenesis of atherosclerosis. A growing number of studies report that inflammation plays a crucial role in the cell biology of atherosclerosis. The aim of the study was to know the relationship between hs-CRP and cardiac markers in acute myocardial infarction patients. This case control study was conducted at the department of Biochemistry and department of Medicine, JSS Medical College, Mysore, Karnataka. The study protocol was approved by Research Ethics Committee of JSS Medical College. A total 60 subjects were included in the study in the age group of 50-68 years. CK-MB, LDH, AST and hs-CRP were estimated. There was a statistically significant difference between the hs- CRP levels of two groups. Cardiac marker values were significantly higher in cases compared to controls. But there was no correlation between cardiac markers and hs-CRP levels in cases. The CRP measurement has a lot of advantages. Firstly it is a stable compound and secondly it can be measured at any time of the day without regards to biological clock. In contrast to results for cytokines such as IL-6, no circadian variation appears to exist for hsCRP. Thus, clinical testing for hsCRP can be accomplished without regard for time of day. In conclusion we would like to say that hs-CRP levels could be used as risk assessment, diagnostic and prognostic marker in myocardial infarction patients.
ABSTRACT
Background and objectives Glycosylated hemoglobin (HbA1c) is a marker of evaluation of long-term glycemic control in diabetic patients and predict risks for the development and/or progression of diabetic complications. Glycosylation process depends on the exposure to glucose. Studies on chronic complications of diabetes established the role of glycosylated hemoglobin (HbA1c) as a marker of evaluation of long term glycemic control and risk for chronic complications. The aim of this study is to evaluate the significance of calculated HbA1c by using fasting plasma glucose levels and comparison with duration of diabetes mellitus. Materials and methods The present study has 2 groups of subjects, 27 normal and 32 diabetic subjects. The diabetic subjects were divided into 2 groups based on complication i,e cataract and nephropathy with duration of diabetes. Plasma glucose was estimated by GOD – POD method. Estimation of glycated hemoglobin was done by calculation. Results and conclusion We found the significance in the duration of diabetes and the levels of glycated hemoglobin and fasting glucose levels were significantly increased in diabetic group as compared to normal subjects (p<0.001). Thus, calculated HbA1c levels can be used with regular checkups of FPG and HbA1c levels in diabetic patients at lesser cost.