1.
Indian J Exp Biol
;
1994 Nov; 32(11): 797-9
Article
in English
| IMSEAR
| ID: sea-59612
ABSTRACT
Chloroquine causes an increase in phospholipid and a decrease in cholesterol in liver mitochondria. A significant decrease in the activities of mitochondrial inner membrane enzymes such as NADH dehydrogenase, succinate dehydrogenase and cytochrome c oxidase is observed. Decrease in cytochrome contents and respiratory control ratio, shown by a decrease in state 3(+ADP) and an increase in state 4 (-ADP), implies decreased ATP synthesis following chloroquine administration. The results confirm drug-induced inhibition of mitochondrial respiration, thereby impairing availability and utilisation of energy.
Subject(s)
Animals , Chloroquine/pharmacology , Male , Mitochondria, Liver/drug effects , Rats , Rats, Wistar
2.
Indian J Exp Biol
;
1987 Sep; 25(9): 637-8
Article
in English
| IMSEAR
| ID: sea-59020