ABSTRACT
Purpose: To evaluate the ameliorative effect of mesenchymal stem cells (MSCs) on acetic acid colitis model via Nrf2/HO-1 pathway in rats. Methods: In this study, 30 rats were divided into three groups. Acute colitis was induced by rectal administration of 4% solution of acetic acid. MSCs were injected intraperitoneally in the treatment group. Results: Increased levels of tumor necrosis factor-α (TNF-α), pentraxin-3, and malondialdehyde (MDA) in colitis group were revealed biochemically. Increased level of TNF-α and decreased levels of Nrf2 and interleukin-10 (IL-10) were observed in rectum tissues. Increased fibrous tissue proliferation, vascularization and inflammatory cell infiltration were described in the colitis group. Significant improvement was observed in MSCs treated group histopathologically. Increased immunopositivity of TNF-α, vascular endothelial growth factor (VEGF) and CD68 markers was observed in the colitis group cells, and decreased level of this positivity was observed in MSCs treated group. Conclusions: Biochemical, histopathological and immunohistochemical results strongly support the ameliorative effect of MSCs against acetic induced colitis model via Nrf2/HO-1 pathway in rats.
Subject(s)
Animals , Rats , Colitis/veterinary , Acetic Acid/adverse effects , Vascular Endothelial Growth Factor A/physiology , NF-E2-Related Factor 2 , Mesenchymal Stem CellsABSTRACT
Introduction: Hydatid disease is a kind of parasitic infection which is caused by Echinococcus granulosus. It is commonly characterized by cystic formation. Almost all organs can be affected by the infection, however, cardiac and especially right ventricular hydatid cystic involvement, is very rare. Also pulmonary artery extension occurs rarely. Case Report: We report herein imaging findings of a -year-old asymptomatic male patient with cardiac hydatid cyst and pulmonary artery extension. He contour lobulation of paracardiac region in the chest. A film was the only clue for making diagnosis. Conclusion: Imaging modalities are heplful in detecting the pathology.