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Obstetrics & Gynecology Science ; : 615-620, 2018.
Article in English | WPRIM | ID: wpr-716660

ABSTRACT

OBJECTIVE: To evaluate the effect of tamoxifen on female reproductive organs in women with breast cancer. METHODS: We retrospectively reviewed the medical records of 309 women with breast cancer who were currently receiving tamoxifen and undergoing regular gynecological examination. RESULTS: We evaluated 92 pre- and 217 postmenopausal women. The prevalence of endometrial thickening was 12% in the pre- and 10.6% in the postmenopausal group. An endometrial biopsy was performed in 43 women and confirmed endometrial cancer in 1, endometrial polyps in 14, and endometrial hyperplasia in 4 women. Transvaginal ultrasonography showed 25 cases of newly developed ovarian cysts. Most ovarian cysts had disappeared during follow-up. CONCLUSION: Tamoxifen use in women with breast cancer causes few complications and is considered safe for female reproductive organs in case of regular gynecological examination.


Subject(s)
Female , Humans , Biopsy , Breast Neoplasms , Breast , Endometrial Hyperplasia , Endometrial Neoplasms , Endometrium , Follow-Up Studies , Gynecological Examination , Medical Records , Ovarian Cysts , Ovary , Polyps , Prevalence , Retrospective Studies , Tamoxifen , Ultrasonography
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