Prevalence of Left Ventricular Diastolic Dysfunction in Metabolic Syndrome as Assessed by Echocardiography

Introduction: Metabolic syndrome is a complex disorderwith high socio-economic cost that is considered aworldwide epidemic. It is very common condition Consistinghyperglycemia,central obesity, hypertension and dyslipidemia(low levels of high density lipoprotein cholesterol(HDL-C)and high levels of triglycerides). Current study was done toassess Left Ventricular Diastolic Dysfunction in patients ofMetabolic Syndrome by 2d- Echocardiography.Material and methods: In this study my aim is to find outthe prevalence of left ventricular diastolic dysfunction inmetabolic syndrome and to highlight the importance ofprimary prevention in metabolic syndrome. The Presentstudy is cross-sectional observational study carried out atCSS Hospital Subharti medical college Meerut UP, consistingof 50 patients having metabolic syndrome according to thecriteria of International Diabetic Federation and to look forthere LVDD via 2d- Echocardiography.Results: The left ventricular diastolic dysfunction grade isassociated with the number of characteristics of metabolicsyndrome. Waist circumference, FBS, E/A, IVRT, Decelerationtime, E/e’ showed a statistically significant association (p value<0.01) with the degree of diastolic dysfunction.Conclusion: The current study showed that, metabolicsyndrome group have an associated abnormal left ventriclediastolic performance So the patients with metabolic syndromeshould receive aggressive therapy to avoid occurrence of heartfailure in the future.

To Study the Serum Cholesterol Levels in the Patients of Sepsis and Prognostic Significance

Introduction: Sepsis is today’s overwhelming and lifethreatning response to infection and recent studies reveal thatserum cholesterol may be a useful prognostic marker of sepsis.Aim: To study the serum cholesterol levels in the patients ofsepsis and its prognostic significance.Material and methods: This was an Prospective Observationalstudy done at CSS Hospital, SVSU Subharti Medical CollegeMeerut U.P. 100 Patients qualifying by fulfilling all inclusionand exclusion criteria and were enlisted in the study afterinformed consent. Serum cholesterol levels were done on theday of presentation and the 3rd day.Result: In the instant study, out of 100 subjects, 48 showedthe rise in the cholesterol with sepsis where as in 52 subjectsshowed decline of cholesterol level. During the study, 52subjects survived whereas 43 subjects expired during thecourse of treatment, 5 subjects left the study group.Conclusion: Monitoring the total cholesterol level can beused as prognostic tool in ICU patients. The level of totalcholesterol at the time of presentation and then the trendwhich is followed by the total cholesterol (increasing trendin total cholesterol level indicates better prognosis of diseaseoutcome and vice versa), is a better marker for prognosis ofthe patient with septicemia in ICU patients

To Study Serum Testosterone Levels in Metabolic Syndrome

Introduction: Metabolic syndrome (Metabolic syndrome)is a complex disorder with high socioeconomic cost that isconsidered a worldwide epidemic. Current research aimed tostudy serum testosterone levels in metabolic syndrome.Material and methods: The present study was ProspectiveObservational study carried out at CSS Hospital, SubhartiMedical College Meerut U.P. 100 patients of metabolicsyndrome were included in the study who fulfilled the IDFcriteria of metabolic syndrome these patients underwentgenral examination, anthropometry,systemic examination,bmi was calculated, different investigation (Fasting LipidProfile, Serum Testosterone Levels,HBA1C, blood sugarlevels). Descriptive analysis of the collected data was done.Correlation of serum testosterone with various componentsof metabolic syndrome was studied using SPSS software tocalculate the level of significanceResults: This study confirmed the high prevalence of lowtestosterone levels in male patients with metabolic syndrome.The total number of patients who had BMI of more than 35 kg/m2, were 18 and all those had low levels of testosterone whichis significant (p value<0.001). The total number of patientswho had triglyceride level of >150, were 80 and all those hadlow levels of testosterone which is significant (p value<0.001).The total number of patients with low testosterone levels inwhom HbA1C was more than 7.5%, were 68. Patients withnormal level of testosterone were 32 in whom HbA1C was6.5-7.5% which is significant (p value<0.001).Conclusion: This study confirmed the high prevalence of lowtestosterone levels in male patients with metabolic syndrome.Multiple associations and predictors of low testosterone levelswere identified by evaluating different demographic, clinicaland other variables.