Hormonal profile as a prognostic index for patients with 1[st] trimesteric threatened abortion

Evidence in the literature is unclear to the exact predictive value of biochemical markers in determining the persistence of threatened abortions. Twenty pregnant women in the 1[st] trimesters, with demonstrable fetal heart pulsations that complained of symptoms, and showed signs of threatened abortion, were included in this prospective, controlled, clinical study. This cohort was divided according to whether or not the pregnancy continued into two groups: Group A1 [N=15] that included patients that had an ongoing pregnancy and Group A2 [N=5] that included patients that had an ineirtabl abortion. A control group of twenty randomly chosen healthy women was used as a control group [Group B]. On the day of inclusion, venous blood samples were taken in order to estimate serum CA-125, hCG, progesterone and estradiol levels, Participants were followed up clinically till the gestational age of 14 weeks to distinguish those who had an ongoing pregnancy compared to those who eventually aborted. Of the twenty patients with threatened abortion fifteen aborted and five continued to fourteen weeks gestation. CA-125 levels were higher, and BHCG, progesterone, and E2 levels were lower, in Group A1 when compared to Group A2 and Group B. Maternal serum CA-125, BHCG, progesterone and estrogen may be of value in predicting patients that will gain from expectant management of threatened abortion

Pregnancy outcome and feto-placental blood flow in hypotensive pregnant women

To examine the effect of maternal hypotension on the feto-placental blood 110w, placental morphology and pregnancy outcome. Observational [prospective]study. Bab El Shaareia and El Hussein University Hospitals, Cairo. The study population consisted of 267 singleton pregnant women between the 26th to 38th week. They were divided into: a study group consisted of 117 hypotensive women with BP?90/60mmHg and a control group of 150 normotensive women with BP between 140/90mmHg. For both groups foetal biophysical profile and Doppler study of the umbilical and middle cerebral arteries were performed every 2-4 weeks. We examined the gestational age at delivery, birth weight, mode of delivery, Apgar score, possible fetomaternal complications and placental gross and microscopical features. In the hypotensive group the mean maternal weight gain was less, the umbilical A/B and RI were higher, middle cerebral artery PI was lower, the biophysical profile was lower, gestational age at delivery, birth weight was lower, Apgar score at 1 min. Was lower, abnormal perinatal outcome were higher, while placental calcification was significantly increased, all when compared to the control group, on the other hand the mean maternal age, mode of delivery, Apgar score at 5min. and placental weight show no significant difference when compared to the control group. Hypotension during pregnancy is a risky condition which we have to care for and hypotensive pregnant women should be monitored all through pregnancy

Outcome of the pregnant women suffering from acute viral hepatitis in Egypt

Seventy-three pregnant women with symptoms and signs of acute viral hepatitis were included in this study. Out of these patients, 36 pregnant women and their newborns could be followed up to two months after labor. All pregnant women were subjected to clinical history and examinations, obstetric status and abdominal ultrasound. The mothers and their babies were clinically followed and HAV IgM, HBsAg, HBcAb, HBcIgM, HBeAg and Ab, delta IgM, HCV Ab, HEV IgG, CMV IgM and EBV IgM were done. The symptoms and signs in pregnant women were similar as in the nonpregnant ones. Pregnancy is not a risk factor for acute viral hepatitis, but the latter may complicate the clinical course of pregnancy. The clinical course of pregnant women was benign in 97.2% and acute fulminant hepatitis was in one case with a morbidity rate of 2.8%. These pregnant women delivered 39 newborns [with three twins]; out of them, five newborns had positive seromarkers as HAV IgM, HBsAg, IE3cIgM, HCV Ab and CMV IgM. Only two newborns were positive HBsAg due to vertical transmission. The vaccination of newborn to positive HBV mother is essential. PCR was recommended for the diagnosis of acute cases with negative seromarkers