ABSTRACT
<p><b>OBJECTIVE</b>To assess the prevalence of colorectal cancer (CRC) in Beijing and the reliability of the sequential fecal occult blood test (SFOBT) for CRC screening.</p><p><b>METHODS</b>Of the natural population (48 100 persons) in several Beijing communities, we screened 26 827 persons with age over 30 using the SFOBT screening program, Guaiacum Fecal Occult Blood Test (GFOBT), Immuno Fecal Occult Blood Test (IFOBT), and colonoscopies.</p><p><b>RESULTS</b>The screening rate of the population was 74%. The positive rate of SFOBT was 5.6%. The prevalence of CRC in the entire population of Beijing was therefore calculated to be 36.57/10(5). Of 12 CRC detected patients, 4 cases were in stage Dukes A (33.33%), 7 cases in stage Dukes B (58.33%), only 1 case (8.34%) in stage Dukes C.</p><p><b>CONCLUSIONS</b>The prevalence of CRC in Beijing is one of the highest in China. Individuals at high risk for CRC or those over 50 years of age should be considered as primary candidates for screening. SFOBT screening is a cost-effective and reliable method for early detection of CRC.</p>
Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , China , Colorectal Neoplasms , Diagnosis , Occult BloodABSTRACT
Objective To investigate the expression an d the role of interleukin 17(IL 17) in patients with ulcerative colitis (UC). Methods IL 17,IL 6 and IL 8 were measured using ELISA technique , and IL 17 mRNA was assayed by RT PCR in 32 patients with UC and compared with 40 controls. The effect of anti IL 17 m onoclonal antibody (MoAb) on production of IL 6 and IL 8 by lamina propria mo nonuclear cells (LPMC) was studied. Results As compared with controls, serum concentrations of IL 17 ,IL 6 and IL 8 from UC patients were significantly higher, but with no statist ic difference. The expression of IL 17 mRNA and secretion of IL 17 by the peripheral blood CD + 4 T cells in UC patients were higher than that in nor mal controls in the presence of stimuli (both P