ABSTRACT
Objective To compare the efficacy between part of ethyl acetate in aerial parts and roots of Astragali Radix (AR), and to provide scientific evidences for the comprehensive utilization of aerial parts of Astragalus membranaceus (APAM). Methods An experimental mouse model of leucopenia was induced by cyclophosphamide, and efficacy indicators combined with NMR based on metabolomic approach were employed to compare the therapeutic effects of part of ethyl acetate in APAM and AR. Results Part of ethyl acetate in APAM and AR increased the contents of white blood cell (WBC), monocytes (MO), lymphocyte (LY), and neutrophils (NE). The levels of six potential endogenous metabolites (isoleucine, leucine, valine, arginine, creatine, and hypoxanthine) were reversed by part of ethyl acetate in APAM, and five potential endogenous metabolites (arginine, aspartate, creatine, GPC, and scyllo-Inositol) were reversed by part of ethyl acetate in AR. Efficacy indexes were 451.83 and 469.17. Conclusion Both parts of ethyl acetate in APAM and AR elevated WBC, the mechanisms of them on leukocytosis were probably related to energy metabolism, amino acids metabolism, choline metabolism, and purine metabolism.
ABSTRACT
Mantle cell lymphoma(MCL)is one of the most frustrating diseases because it exhibits the worst features of both aggressive non-Hodgkin Lymphoma(NHL)and indolent NHL.It develops rapidly like the former,and it is incurable and lacks of better therapeutic options like the latter.Clinical researchs confirm the activity of rituximab as a single agent and combination regimens(R-Chemo)in the treatment of MCL. Bortezomab is also active in treating patients with MCL and requires further study in combination regiments. The usages of mTOR inhibitor and radioimmunotherapy represents a novel therapeutic approaches in the treatment of MCL.It is also deserved to study.