Meningeal carcinomatosis in bladder transitional cell carcinoma

Meningeal carcinomatosis is a rare event in bladder transitional cell carcinoma. In this report, we present a man with transitional cell carcinoma who developed brain metastasis followed by spinal and leptomeningeal involvement

Renal oncocytoma, benign or malignant?

Introduction: Renal oncocytoma is a benign renal tumor, which is commonly asymptomatic and discovered incidentally with diagnostic imaging. This benign tumor occasionally co-exists with a malignant neoplasm, which may be present within or near the oncocytoma; in addition a few rare cases of renal oncocytoma have simulated a malignant course, showing extension to branches of the renal vein or distant metastasis

Report of the Case: A rare case of renal oncocytoma has been reported in a 56 year- old woman, who referred with distant metastatic disease

Primary pulmonary Hodgkin's disease [case report]

Lung involvement in Hodgkin's disease is usually associated with nodal involvement and is due to direct extension from mediastinal nodes. Primary pulmonary Hodgkin's disease is a rare disease. This disease occurs most frequently in the older women. The present case was a 54-year-old woman who was presented with fever, dry cough and weight loss since the last three months. There was no evidence of hepatosplenomegaly and peripheral lymphadenopathy. Radiological investigations revealed bilateral pulmonary nodular lesions but no mediastinal lymphadenopathy. Cyto-pathology assessment of the sample which was taken based on bronchoscopic and CT results did not help with diagnosis of the disease. As a last resort, open lung biopsy was done and a diagnosis of Hodgkin's disease was made. The final diagnosis was primary pulmonary Hodgkin's disease. Although primary pulmonary Hodgkin's is a rare disease, it should be considered as one of the causes of bilateral pulmonary nodular lesions

Efficacy of Iranian hydrogel on wound healing in rat as an animal model

Hydrogels are one of the commonly used dressings for chronic ulcers. Nowadays, much therapeutics can be delivered to the wound or circulation by the gels. This study was conducted to evaluate the efficacy of Iranian hydrogel in wound healing in rat as an animal model. Thirty four Wistar male rats were anaesthetized and a full thickness circular skin wound was created by excising the dorsum of the rats. The animals were divided into two groups. In the experimental Ir gel group, the wounds were dressed by hydrogel and in the control NS group by conventional moist normal saline gauze. The wound areas were measured on days 1, 3, 7 and 12 for comparing the wound healing rate in the two groups. Laboratory investigation, skin tensile strength and histopathology of the healed tissues were also considered for evaluation. Mean percentages of wound contraction on the 3rd, 7th and 12th days were not significantly different between the two groups. The differences in skin tensile strength, in the two groups, on days 15 and 30 were not significant. Histopathologically, wound repair was excellent in 6 [60%], good in 3 [30%] and poor in 1 [10%] of specimens in control NS group while these figures were 6 [60%], 4 [40%] and 0 [0%] in the Ir gel group respectively and the difference was not statistically significant. The effect of Iranian hydrogel effect on wound healing in rats was identical to moist gauzes. As Iranian hydrogel did not have any adverse effects and was easily removed from the wound, it can be safely used for dressing wounds

[ case of resistant megaloblastic anemia responding to thiamine]

Thiamine responsive megaloblastic anemia [TRMA], also known as Roger syndrome is an autosomal recessive disorder resulting from the deficiency of thiamine [Vitamin B1] transporter protein. This is the report of a 3-year follow up of a female child who presented in 2000 at the age of 11 with severe anemia, congenital deafness and diabetes mellitus. In our follow-up period we prescribed 100-mg thiamine tablet daily and after that there was a rise in her hemoglobin level to normal. Her hyperglycemia was controlled during the early phase of treatment. It recurred several months after start of treatment, but needed lower doses of insulin for control. Hearing loss did not respond to thiamine. Presently, the patient is apparently in good condition with normal hemoglobin level

[Rate of prevalence of helicobacter pylori infection in primary gastric lymphoma patients referring to pathology centers of Yazd]

Lymphomas as a group rank seventh as the most leading cause of death in cancers. Stomach is the most common extra nodal site of primary lymphomas. On the other hand, new information demonstrates that MALT lymphoma responds to Helicobacter antibiotic therapy. We therefore decided to determine the frequency of distribution of Helicobacter Pylori infection in primary gastric lymphoma cases at the pathology centers of Yazd and determine the relationship of Helicobacter Pylori infection with sex, age and chief complaint of these patients. This was a case series and cross-sectional study and population included patients referring to pathology centers of Yazd for whom diagnosis of primary gastric lymphoma had been suggested. Required data was accumulated with assessment of pathology reports and hospital folders of patients. Also, tissue blocks of studied patients were evaluated for presence or absence of Helicobacter Pylori. After completing the questionnaire, data was analyzed statistically using SPSS 13, ANOVA and Fisher's Exact tests. 28 patients were included in this study. Prevalence of Helicobacter Pylori infection in the study group was 43.5% and more in female patients and patients aged above 45 years. Helicobacter Pylori infection was more in patients who had dyspepsia as their chief complaint and those with ulcer on endoscopy. Also, the frequency was more in high grade lymphoma cases. In this study we didn't achieve a statistically significant correlation between primary gastric lymphoma and Helicobacter Pylori infection. We suggest further studies with larger number of cases to determine the prevalence of various grades of lymphoma and their relationship with Helicobacter Pylori in other provinces with conditions similar to Yazd

[ case report of inflammatory myopathy and sideroblastic anemia]

Mitochondrial myopathy, lactic acidosis, and siderobastic anemia [MLA SA] syndrome is one of the newly reported mitochondrial diseases, seven cases of which have been reported. We report a child with inflammatory myopathy, sideroblastic anemia and lactic acidosis .The patient is a 8.5 year old boy with normal cognitive function suffering from chronic progressive weakness in lower extremities, inability to walk since four months and pallor. In paraclinical evaluation, sideroblastic anemia, mild lactic acidosis and elevated muscle enzymes were seen. Inflammatory myopathy [myositis] in muscle biopsy was detected as well .The patient was administered oral prednisolone, folic acid, B[6] and underwent regular physiotherapy. He ambulated after four months and resumed education and schooling