correlation between semen parameters in processed and unprocessed semen with pregnancy rate in intrauterine insemination in the treatment of male factor infertility

Our aims were to determine the relation of semen parameters in processed and unprocessed semen samples with pregnancy rate in intrauterine insemination [IUI] in the treatment of male factor infertility. In a quasi experimental study, 412 couples with male factor infertility were studied. To treat male factor infertility, 561 IUI cycles were done. Total pregnancy rate was 7.84% [44 in 561] per cycle. There was an inverse relationship between pregnancy rate and duration of infertility.Total sperm count after processing was higher in pregnant cycles than in non-pregnant ones [P<0.05]. The mean total motile sperms after processing for pregnant and non-pregnant cycles was 72.2 +/- 78.8 and 53.2 +/- 54.3, respectively [P<0.05]. IUI is a valuable method for the treatment of male factor infertility. The higher number of sperms, total motile sperms and IUI sessions, and lower duration of infertility, all have a positive relationship with pregnancy rate

[Evaluation of the relationship between ovarian dysgermlnomas and the results of DNA analysis]

This paper studies the relationship of DNA analysis ploidy and stage of ovarian dysgerminoma and its prognosis with flowcytometric evaluation. The files and specimens from 24 cases [mean age 18/2+/-4/5 years] seen at Mirza Kouchak khan and Imam Khomeini hospitals between 1992 and 1997 were assessed and the patients followed for period of five years. There were 11 cases [45/8%] in stage I, 2 [8.3%] in stage II, 7 [29.2%] in stage III and 4 [16.7%] in stage IV. DNA aneuploidy was revealed in 13[54.2%] of tumors. There were 6 [15%] deaths, 7 [29.2%] recurrences and 11 [45.8%] free from the disease during the follow-up. DNA ploidy was significantly related to prognosis [p = 0.0006] and stage [x[2] = 15.9, p = 0.04]. The deaths and recurrences in cases with DNA aneuploidy were 30.5% and 53.8% respectively; only 7.7% were free. The most frequent aneuploidy was in stage III and IV [85/7% and 75% respectively]. Within microscopic data, mitosis, pleomorphism, necrosis and hemorrhage significantly related to DNA ploidy [p< 0.05]. The frequency of aneuploidy was greater in mitosis > 8 in HPF, higher pleomorphism and presence of necrosis and hemorrage. Our study revealed that DNA aneuploidy in ovarian dysgerminoma is related to higher staging and poor prognosis