ABSTRACT
A correlative clinical, endoscopic, histopathological, histochemical and plasma 5-HT level study was done in 25 patients with hepatosplenic billharziasis recovered from upper gastrointestinal bleeding and 10 controls.Significant hyperplasia and hyperactivity of enterochromaffin [EC] cells in the gastroduodenal mucosa was found in all patients associated with significant increase in plasma serotonin [5-HT] level.This detected hyperserotoninaemia can be attributed not only to the defective hepatic degradation but also to over production by hyperplastic and hyperactive EC-cells. Increased plasma 5-HT level may have a double share in the causation of upper gastrointestinal bleeding by elevation of the portal blood pressure and the induction or gastroduodenal erosions found in patients with hepatosplenic bilharziasis
Subject(s)
Schistosomiasis , Gastrointestinal Hemorrhage , Enterochromaffin CellsABSTRACT
The oral antischistosomal drugs [vansil and biltricid] were investigated experimentally on albino rats with paracetamol induced hepato-renal toxicity. A biochemical and histopathological studies were done on such animals and were compared with normal and paracetamol treated ones. It is found that vansil is less toxic than biltricid as the last one causes more hepatorenal affection together with pulmonary congestion which is lacking in the vansil treated ones. Both drugs produce no testicular changes