ABSTRACT
Data available suggests that Adiponectin, an adipocyte-derived peptide, is associated with adiposity and could effect the regulation of glucose and lipid metabolism in humans. The aim of this study was to evaluate the association between serum adiponectin concentrations and anthropometric indices and lipid profiles among Iranian women with different grades of obesity. In this analytical descriptive study of 157 non-diabetic women [33 normal weight, BMI< 25 kg/m2 and 124 overweight and obese, BMI >/= 25kg/m2], serum adiponectin and leptin levels were measured using an enzyme-linked immunoassay. Fasting glucose and lipid profile levels determined by the glucose oxidize and enzymatic methods, respectively. Mean serum adiponectin concentration significantly decreased with obesity [p<0.05]. Although adiponectin showed a significant negative correlation with BMI [r=-0.321], it was correlated with serum leptin [r=-0.139], glucose [r=0.259], LDL-C [r=-0.125], TGs [r=-0.210] levels, TSF [r=-0.145], WHR [r=-0.159], and positively with serum HDL-C concentration [r=0.218] in all subjects [p<0.05]. Results of multiple regression analyses showed that adiponectin as a dependent variable had a significant correlation with BMI [beta =-0.605, P=0.017], waist circumference [beta =0.624, p=0.029], WHR [beta =-0.251, p=0.048], frame [beta =0.260, p=0.018], TC/HDL-C ratio [beta =-0.1.309, p=0.040] and LDL/HDL ratio [beta =-1.343, p=0.007] and changes in waist size had a significant effect on serum adiponectin levels. Our results suggested that adiponectin had an inverse correlation with adiposity indices and unfavorable lipid profiles, and that variation of waist circumference mostly affected Iranian women
ABSTRACT
Background and Objective: leptin is a 16 KDa peptide which has a close correlation with adiposity. However, its effect on lipid profile is controversial in human. Therefore, this study was performed to investigate correlation between variations in serum leptin levels with lipid profile and anthropometric indices in women with different grades of obesity
Materials and Methods: the current cross-sectional study was carried out on 149 healthy non diabetic women, including 33 normal weight [BMI<24.9 kg/m2] and 116 women with different grades of obesity [BMI>25 kg/m2] with age range of 15-49 years, respectively. Serum levels of leptin, fasting blood glucose and lipid profile [total cholesterol, triglyceride and HDL-cholesterol] were measured using high sensitive immunoassay, glucose oxidase and enzymatic methods, respectively
Results: mean serum leptin levels were 15.34, 32.78, 42.13, 43.22 and 45.23 ng/ml in normal, overweight, obese grade I, obese grade II, and obese grade III women, respectively. Difference in mean of leptin serum level, lipid profile, and anthropometric indices was statistically significant between different groups [p<0.001]. Leptin Serum levels had significant correlation with BMI [p<0.05, r=0.623]. In addition, it showed a direct significant correlation with levels of fasting blood glucose [r=0.297] and lipid profile [total cholesterol [r=0.347], triglyceride [r=0.428], and LDL-cholesterol [0.367]] [p<0.05]. In contrast, it showed an indirect correlation with HDL-C serum levels [r= -0.320, p<0.05]
Conclusion: results of the current study showed that leptin serum level has a close direct correlation with adiposity indices and lipid profile and its level increases significantly with increasing grades of obesity