Buccoadhesive tablets for delivery of verapamil hci: design, in-vitro analysis and in-vivo evaluation

Buccoadhesive controlled release verapamil HCI tablets have been prepared using mucoadhesive polymers namely; sodium alginate [Na Alg], xanthan gum [XG] and gum tragacanth [GT] either alone or in combination in different ratios 2:8, 8:2, 4:6 and 6:4. The prepared tablets were evaluated for their weight variation, thickness, hardness, friability and dissolution, content uniformity, swelling index, in-vitro adhesion, in-vitro drug release and in-vivo hypertension study. Tablets containing XG showed the highest swelling index and bio adhesive force. The maximum cumulative% released [100%] was observed in F7, F10 and FJl due to high percent of Na alg. The kinetics studies show that the release follows zero order kinetics except Fl that it obeyes a diffusion model The buccoadhesive verapamil HCI tablet had suggested being promising for the transmucosal delivery of verapamil HCI and allowing a controlled drug delivery for 6 hrs

Enhancement of skin permeability of guinea pig in presence of riboflavin and light

The permeability of a slightly stripped skin of guinea pig, to lactose isonicotinoylhydrazone [L-INH], in the presence of riboflavine and light, was studied. A very marked increase in the permeability of skin to L-INH, when the experiments were carried out in the presence of light, compared to those in the dark, was demonstrated. This was ascribed to an interaction between photodecomposition products of riboflavine and certain components of the skin which caused an alteration in permeability of the membrane