ABSTRACT
Objective:To explore characteristics and interventional treatment of the elderly patients with chronic total occlusion of coronary artery. Methods:According to the age,146 cases of coronary heart disease received interventional treatment of chronic total occlusion from Feb 2012 to Mar 2016 were divided into elderly group and youth group. Comparative analysis of characteristics and prognosis between the two groups was done. Results:The proportion of family history of coronary heart disease in elderly group was significantly lower than that in the young group (P<0.05), the incidence rate of occlusive vascular calcification or tortuosity and surgical intervention time were significantly higher than those in the young group (P<0.05) . After interventional treatment, LVEDD in elderly group was significantly lower than that in the young group (P<0.05),and LVEF,left ventricular aneurysm and wall motion abnormality rate had no significant differences (P>0.05) . Conclusions:Elderly patients with chronic total occlusion of coronary artery prone to calcification or tortuosity, interventional treatment takes a long time, success rate and adverse cardiovascular events had no difference compared with the young, postoperative cardiac function of elderly patients improved more obviously.
ABSTRACT
The changes of CaM content and distribution in acute cerebral ischemia of Mongolian gerbils were investigated with enzyme-linked immuno-sorbent assay (ELISA )and immunogold staining(IGS). The ELISA results showed that which ligation of both common carotid arteries for 10 rain the contents of CaM were significantly lower (P
ABSTRACT
The effects of bepridil, ni-modipine and nicardipine on the activity of CaM - dependent protein kinase Ⅱ from mouse cerebrum were studied in vitro. Tt was found that bepridil significantly inhibitied the activity of CaM - PK Ⅱ with an IC50 value of 0. 3 mmol ? L-1. but nimodipine and nicardipine did not basi-cally influence the activity of the enzyme. The experimental results showed that the inhibitory effect of bepridil on the activity of CaM - PK Ⅱ was an antagonistic action of bepridil to CaM.