Age specific histologic types of carcinoma breast in Malaysians

The influence of age on various histological types of breast cancer at both age < 50 years and > 50 years to simulate menopause was studied retrospective from 2002 to 2004 in Malaysia. One hundred and fifty five cases were reviewed. Ninety two cases recorded at age < 50 years, 60 [65.2%, 95%CI: 54.6 - 74.8%] were infiltrating ductal carcinoma in 11[12.0%, 95% CI: 6.1-20.4%], ductal carcinoma in situ [DCIS] in 9 [9.8%, 95% CI: 4.6-17.8%], medullary carcinoma in 6 [6.5%, 85%CI: 2.4-13.6%], invasive lobular carcinoma in 4 [4.3%, 95%CI: 1.2-10.8%], mucinous carcinoma and poorly differentiated carcinoma in 2 cases [2.2%, 95%CI: 0.3-7.6%]. At > 50 years of age, 63 cases were recorded. Forty seven [74.6%, 95%CI: 62.0- 84.7%] cases were of infiltrating ductal carcinoma, ductal carcinoma in situ in 9 [14.3%, 95%CI: 6.7-25.4%], mucinous carcinoma in 5 [7.9%, 95%CI: 2.6-17.6%], medullary carcinoma [8.5%] and papillary carcinoma in 1 case each [1.6%, 95%CI: 0.0-8.5%]. Infiltrating ductal carcinoma was the commonest histology at both age < 50 years and > 50 years

Hereditary spherocytosis in a Malay patient with chronic haemolysis

This case report describes a 35-year-old lady who presented with generalized weakness and lethargy of two weeks duration and jaundice of more than 20 years duration. Her initial workup was suggestive of haemolysis and blood film showed a leucoerythoblastic picture with moderate microspherocytes. She was finally diagnosed as a case of hereditary spherocytosis after ruling out other possible causes of chronic haemolysis and supported by an abnormal osmotic fragility test, although family members refused for screening. Hereditory spherocytosis is uncommon in Malay population and presentation with jaundice of 20 years duration with leucoerythroblastic picture on blood film were interesting features in this case. Patient is being followed closely for need of splenectomy in near future as per severity of haemolysis and currently being managed with folic acid supplement.

Bone involvement in hodgkin's disease at presentation: a series of three case reports with a brief review

Most patients with Hodgkin's lymphoma present with the disease. On staging workup, all the three patients progressive painless lymphadenopathy. Very few patients were found to have bony lesions at the time of diagnosis, have presented with bony involvement at the time of confirmed by imaging studies. All patients were treated diagnosis. We report on three cases of Hodgkin's with chemotherapy and radiotherapy directed at their lymphoma who presented with signs and symptoms of bony lesions. bone involvement in addition to other clinical features of the disease on rtaging work up, all the three patients were found to have bonylerions at the time of cliagnosin confivmed by imaging rtudgies. all patients were treated with chemotheraby and radio theraty directed at their bany lesions