Spectrofluorimetric determination and kinetic study of ceftibuten

In this work, a simple and sensitive spectrofluorimetric method was developed to study ceftibuten degradation. It was also applied for the indirect determination of drug in bulk and pharmaceutical capsules. The procedure was based on the reaction of the degraded product with the fluorogenic reagent, fluorescamine. The proposed analytical method was optimized and validated. The detection limit was 0.1035 mug/ml. The activation energy for the degradation was 2.607 Kcal mol1

Spectrophotometric investigation of lincomycin and clindamycin-palladium [II] complexes and its application for their assay in capsules and ampoules

Palladium [II] chloride is proposed as a chromogenic reagent for the determination of lincomycin or clindamycin hydrochloride. The yellow complex is produced by the reaction of lincomycin or clindamycin HCl with Pd [II] in an aqueous solution of pH 4.7 or 5.5, respectively, and at ionic strength of 0.2 M KCl. The color has an absorption maximum at 380 nm with molar absorptivities of 1.86 x 103 and 1.68 x 103 1 mol-1 in concentration ranges of 10-140 and 20-170 mugml-1 for lincomycin and clindamycin, respectively. The precision, composition and conditional stability constant of the yellow complex have been established. The reagent has been successfully used for the spectrophotometric determination of these drugs alone and in pharmaceutical preparations