Objective Evidence of Inducible Ischemia in Patients with Ischaemic Heart Disease by Global Longitudinal Strain During Dobutamine Stress Echocardiography

Background: Operator dependent two-dimensional (2D) echocardiography is a noninvasive test to assess myocardial hypokinesia. Inter observer variability is more as it is subjective. Objective evidence of 2D global longitudinal strain (2D GLS) and strain rate imaging are getting popularity. Methods: This cross sectional study was done on 20 patients who came for dobutamine stress echo (DSE) in the department of cardiology of BSMMU, Dhaka from 1st February 2019 to 31st July 2019. 2D GLS was done before and just after DSE. Results: DSE findings revealed 6 patients had viable LAD, 9 had viable LCX and 6 had viable RCA, 9 had nonviable LAD, 2 had nonviable LCX and 3 had nonviable RCA territories. Difference in Post-systolic strain rate (SRps) in myocardial segments supplied by LAD at baseline peak stress in patients who had normal and nonviable LAD (-21% to. -23%, p=0.98) and (-6%to – 7%, p= 2.87) which were not significant. At peak exercise there was a trend towards greater SRps in viable territory of LAD in compared with baseline and peak stress (-1% to -16%, P = 0.05) which was significant. SRps in myocardial segments supplied by LCX at baseline and peak stress in patients who have normal and nonviable LCX (-20% to. -21%, p=0.82) and (-5%to – 5%, p=1.18) which had similar result as LAD territory. At peak exercise there was a trend towards greater SRps in viable territory of LCX compared with baseline and peak stress (-12% to -15%, P = 0.06). There was no significant difference in SRps in myocardial segments supplied by RCA at baseline and peak stress in patients who had normal and nonviable RCA (-23% to. -24%, p=1.72) and (-4%to – 5%, p=2.10). At peak exercise there was a trend towards greater SRps in viable territory of RCA compared with baseline and peak stress (-10% to -15%, P = 0.04). Conclusion: Results of subjective interpretation of DES has compared with objective evidence 2D GLS on peak stress which has similarity. It was a small study. Future large study is needed to establish these findings.

3-[[2-chloroquinolin-3-yl]methyl]quinazolin-4[3H]-ones as potential larvicidal agents

The larvicidal effect of series of 3-[[2-chloroquinolin-3-yl]methyl]quinazolin-4[3H]-ones, 5a-e, against Chironomus tentans Fabricius has been investigated. The results showed that tested compounds demonstrated strong larvicidal activity, and caused high percentage of mortality after 24 h at the doses of 40-100 microg/ml, especially in the case of 3-[[2-chloro-8-methyquinolin-3-yl]methyl]quinazolin-4[3H]-one, 5b, that act as a promising larvicidal agent

burden of road traffic injuries in South Asia: a commentary

Around 238,000 people die in road crashes every year in South Asian countries. However, no information on road traffic injuries in South Asian countries is available to estimate the magnitude of the problem in terms of the various levels of severity. It has been estimated that for one RTI death, there are 20 hospitalizations, 50 emergency room visits, and more than 100 minor injuries. Together with the social impact in terms of pain, grief and suffering, RTIs impose a very large economic burden on the countries affected. Considering a gross estimate of 1% of GDP as economic loss from RTIs in South Asian countries runs into US$ 25 billion a year which is more than 50% the total annual amount of development assistance worldwide. The main reasons for high burden of road traffic injuries in this region are growth in the number of motor vehicles, poor enforcement of traffic safety regulations, poor quality of roads and vehicles, and inadequate public health infrastructures

Otitis in Children

This study had conducted in the ENT out patient department of Rajshahi medical college Hospital and Microbiology department of Rashahi Medical College during the period April 2001 to July 2001. Out of 48 cases, the prevalence of only bacteria, only fungus and both bacteria and fungus cases were 45.83%, 16.66% and 37.50%respectively. Maximum [25%] numbers of cases were from age group 2.5 to 3.5 years. Only bacteria cases were common in the younger age group [0.5 to 3.5year] and only fungal cases were common with increase of age [3.5 to 6.5 years]. There was no specific relationship of age with both bacteria and fungal cases. Among the fungal causes candida albicans was predominant followed by Aspergillus spp. and occasionally Rhizopus spp. The isolated bacteria were Esh.coli, Staph. aureus, strept. Pyogens, proteus and pseudomonas. Male was 28 [58.33%] and female was 20 [41.67%] and female was 20 [41.67%] and majority cases were from urban area