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1.
Med. U.P.B ; 42(1): 67-75, ene.-jun. 2023. Ilus, tab
Article in Spanish | LILACS, COLNAL | ID: biblio-1416195

ABSTRACT

El tinnitus o acúfeno es la percepción de sonido en ausencia de un estímulo acústico externo; es uno de los motivos de consulta más comunes en el área de otorrinolaringolo­gía. Se ha asociado a diversas etiologías tales como ototoxicidad, tumores, traumatismo craneoencefálico y trastornos psiquiátricos, siendo también las causas de carácter idio­pático ampliamente conocidas. Las características clínicas de los tinnitus son variables de paciente a paciente, por lo que su diagnóstico, tratamiento y seguimiento son un desafío clínico Si bien recientes estudios han propuesto distintos manejos clínicos y terapéuticos, estos continúan hoy en día en estudio. Esta revisión narrativa pretende realizar una actualización sobre el abordaje diagnóstico, clínico y terapéutico de los tinnitus en la última década.


Tinnitus, the perception of sound in the absence of an external acoustic stimulus, is one of the most common reasons for consultation in the area of otorhinolaryngology. It has been associated with various etiologies such as ototoxicity, tumors, head trauma, and psychiatric disorders; idiopathic causes are also widely known. The clinical characteristics of tinnitus are variable from patient to patient; therefore, its diagnosis, treatment, and follow-up are a clinical challenge. Although recent studies have proposed different clinical and therapeutic approaches, these are still under analysis today. This narrative review aims to update the diagnostic, clinical and therapeutic approach to tinnitus in the last decade.


Tinnitus ou zumbido é a percepção do som na ausência de um estímulo acústico externo; é um dos motivos mais comuns de consulta na área de otorrinolaringologia. Tem sido associada a várias etiologias, como ototoxicidade, tumores, traumatismo craniano e distúrbios psiquiátricos, sendo também amplamente conhecidas causas idiopáticas. As características clínicas do zumbido são variáveis de paciente para paciente, por isso seu diagnóstico, tratamento e acompanhamento são um desafio clínico, embora estudos recentes tenham proposto diferentes abordagens clínicas e terapêuticas, ainda hoje estão em estudo. Esta revisão narrativa visa atualizar a abordagem diagnóstica, clínica e terapêutica do zumbido na última década.


Subject(s)
Humans , Tinnitus , Otolaryngology , Sound
2.
Rev. argent. cardiol ; 90(5): 359-362, set. 2022. tab
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1529531

ABSTRACT

RESUMEN Introducción: La Resonancia Magnética Cardíaca (RMC) es cada vez más frecuentemente utilizada en pacientes con Distrofia Neuromuscular de Duchene y Becker (DMD y DMB). Por la capacidad de demostrar realce tardío con gadolinio (RTG), que identifica zonas de fibrosis de la pared media y subepicárdica, subendocárdica o global, y el cálculo de la fracción de eyección ventricular izquierda (FEVI), se considera el patrón oro en el diagnóstico y pronóstico de la afección cardíaca de estas distrofias. Objetivos: Determinar por medio de RMC la presencia de fibrosis cardíaca en pacientes con distrofia neuromuscular. Determinar el compromiso neuromuscular y cardiaco. Definir la evolución cardiovascular de estos pacientes Material y métodos: Se realizó un estudio descriptivo de corte transversal de 16 pacientes consecutivos desde marzo de 2021 a julio de 2022 en el Área de imagen cardiaca de CEMET (Centro Médico Tafi Viejo) y Diagnóstico Médico Dr. Gaya de la provincia de Tucumán. Resultados: Se evaluaron 16 pacientes, todos con diagnóstico confirmado de DMD/DMB por laboratorio, enzimas, y test genéticos. La edad promedio fue 19 años. Todos tenían estadio grave de la escala de Vignos y tratamiento neurológico. Todos tenían tratamiento con betabloqueantes o inhibidores de la enzima de conversión de la angiotensina. La RMC evidenció que 4 pacientes tenían deterioro grave de la FEVI (<35%); 8 pacientes tenían trastornos segmentarios o globales de la motilidad parietal del VI y en 12 se observó RTG, de distribución variable: difusa, mesocárdica, subendocárdica y subepicárdica. En 6 pacientes se observó miocardio no compacto y en 2 derrame pericárdico leve. Conclusión: La RMC debe ser incluida como método de cribaje para pacientes con distrofias neuromusculares. Su aporte para la estadificación clínica y terapéutica es de suma importancia.


ABSTRACT Introduction: Cardiac magnetic resonance imaging (CMR) is commonly used in patients with Duchene (DMD) and Becker (DMB) Neuromuscular Dystrophies. Late gadolinium enhancement (LGE) identifies areas of middle, subepicardial, or subendocardial wall fibrosis, and volumetric left ventricular ejection fraction (LVEF) is considered the gold standard in the diagnosis and prognosis of these dystrophies. Myocardial fibrosis occurs in patients with neuromuscular dystrophies. The purposes of our study were to determine the presence of cardiac fibrosis using CMR, to determine neuromuscular and cardiac involvement, and to evaluate the cardiovascular outcomes of these patients. Methods: A descriptive cross-sectional study of 16 consecutive patients was conducted from March 2021 to July 2022 in the Cardiac Imaging Service of Diagnóstico Médico and CEMET- Tucumán. Results: A total of 16 patients were evaluated, 100% of them with confirmed diagnosis of DMD/DMB by laboratory, enzymes and genetic tests. Mean age was 19 years. All patients had severe stage of the Vignos Scale and were under neurological treatment. All patients were also treated with beta-blockers or angiotensin-converting enzyme inhibitors. CMR revealed severe LVEF impairment <35% in 4 patients, segmental or global left ventricular (LV) wall motion disorders in 8 patients, and variable distribution pattern (diffuse, mesocardial, subendocardial and subepicardial patterns) of LGE in 12 patients. Non-compacted myocardium was observed in 6, and mild pericardial effusions in 2 patients. Conclusion: CMR should be included as a screening method in patients with neuromuscular dystrophies. Its contribution to clinical, echocardiographic and therapeutic staging is of utmost importance.

3.
Braz. j. biol ; 82: 1-7, 2022. tab
Article in English | LILACS, VETINDEX | ID: biblio-1468437

ABSTRACT

Microbiological studies of the sanitary and health status of psittacine birds that will be reintroduced is important in evaluating whether these animals act as carriers of pathogenic agents to other animals and humans. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a faster and more accurate method to identify bacteria than conventional microbiology methods. The aim of this study was to evaluate the health status of psittacines housed in captivity, by assessment of Gram-negative bacteria from fecal microbiota through MALDI- TOF MS identification. The results indicate high frequency of Gram-negative bacteria in feces (96.5%), especially from the Enterobacteriaceae family (88.7%). The most prevalent bacteria were Escherichia coli (39.0%), Proteus vulgaris (12.2%), Klebsiella spp. (12.1%) and Raoultella ornithinolytica (8.7%). Proteus hauseri, Citrobacter spp., Morganella morgannii, Providencia rettgeri, Enterobacter spp. and Escherichia hermannii were isolated with lower frequency. . All these agents are potentially pathogenic for parrots and can cause systemic infections in other animals and humans. These findings reinforce that MALDI- TOF MS proved to be a rapid and accurate method of identification of the microorganism and evaluation of the health status of psittacines, providing relevant data to assist decision-making regarding the sanitary protocols in wildlife centers, and possible future reintroduction of wild birds.


Estudos microbiológicos da sanidade de psitacídeos que serão reintroduzidos são importantes para avaliar se esses animais atuam como portadores de agentes patogênicos para outros animais e humanos. A espectrometria de massa por ionização/dessorção de matriz assistida por laser/tempo de vôo (MALDI-TOF MS) é um método mais rápido e preciso para identificar bactérias na comparação com métodos convencionais de microbiologia. O objetivo deste estudo foi avaliar o estado de saúde de psitacídeos cativos, identificando bactérias Gram-negativas da microbiota fecal por MALDI -TOF MS. Os resultados indicaram alta frequência de bactérias Gram-negativas nas fezes (96,5%), principalmente da família Enterobacteriaceae (88,7%). As mais prevalentes foram Escherichia coli (39,0%), Proteus vulgaris (12,2%), Klebsiella spp. (12,1%) e Raoultella ornithinolytica (8,7%). Proteus hauseri, Citrobacter spp., Morganella morgannii, Providencia rettgeri, Enterobacter spp. e Escherichia hermannii foram isolados com menor frequência. Todos esses agentes são potencialmente patogênicos para os papagaios e podem causar infecções sistêmicas em outros animais e seres humanos. Esses achados reforçam que o MALDI- TOF MS é um método rápido e preciso de identificação do microrganismo e avaliação do estado de saúde dos psitacídeos, fornecendo dados relevantes para auxiliar na tomada de decisões sobre os protocolos sanitários em centros de triagem de animais selvagens e sobre a possibilidade de reintrodução futura.


Subject(s)
Animals , Gram-Negative Bacteria/pathogenicity , Enterobacteriaceae/pathogenicity , Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization , Parrots/microbiology
4.
Braz. j. biol ; 822022.
Article in English | LILACS-Express | LILACS, VETINDEX | ID: biblio-1468624

ABSTRACT

Abstract Microbiological studies of the sanitary and health status of psittacine birds that will be reintroduced is important in evaluating whether these animals act as carriers of pathogenic agents to other animals and humans. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a faster and more accurate method to identify bacteria than conventional microbiology methods. The aim of this study was to evaluate the health status of psittacines housed in captivity, by assessment of Gram-negative bacteria from fecal microbiota through MALDI- TOF MS identification. The results indicate high frequency of Gram-negative bacteria in feces (96.5%), especially from the Enterobacteriaceae family (88.7%). The most prevalent bacteria were Escherichia coli (39.0%), Proteus vulgaris (12.2%), Klebsiella spp. (12.1%) and Raoultella ornithinolytica (8.7%). Proteus hauseri, Citrobacter spp., Morganella morgannii, Providencia rettgeri, Enterobacter spp. and Escherichia hermannii were isolated with lower frequency. . All these agents are potentially pathogenic for parrots and can cause systemic infections in other animals and humans. These findings reinforce that MALDI- TOF MS proved to be a rapid and accurate method of identification of the microorganism and evaluation of the health status of psittacines, providing relevant data to assist decision-making regarding the sanitary protocols in wildlife centers, and possible future reintroduction of wild birds.


Resumo Estudos microbiológicos da sanidade de psitacídeos que serão reintroduzidos são importantes para avaliar se esses animais atuam como portadores de agentes patogênicos para outros animais e humanos. A espectrometria de massa por ionização/dessorção de matriz assistida por laser/tempo de vôo (MALDI-TOF MS) é um método mais rápido e preciso para identificar bactérias na comparação com métodos convencionais de microbiologia. O objetivo deste estudo foi avaliar o estado de saúde de psitacídeos cativos, identificando bactérias Gram-negativas da microbiota fecal por MALDI -TOF MS. Os resultados indicaram alta frequência de bactérias Gram-negativas nas fezes (96,5%), principalmente da família Enterobacteriaceae (88,7%). As mais prevalentes foram Escherichia coli (39,0%), Proteus vulgaris (12,2%), Klebsiella spp. (12,1%) e Raoultella ornithinolytica (8,7%). Proteus hauseri, Citrobacter spp., Morganella morgannii, Providencia rettgeri, Enterobacter spp. e Escherichia hermannii foram isolados com menor frequência. Todos esses agentes são potencialmente patogênicos para os papagaios e podem causar infecções sistêmicas em outros animais e seres humanos. Esses achados reforçam que o MALDI- TOF MS é um método rápido e preciso de identificação do microrganismo e avaliação do estado de saúde dos psitacídeos, fornecendo dados relevantes para auxiliar na tomada de decisões sobre os protocolos sanitários em centros de triagem de animais selvagens e sobre a possibilidade de reintrodução futura.

5.
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1407805

ABSTRACT

Resumen La viruela del simio (MPX) es una enfermedad tropical zoonótica, endémica de algunas zonas de África, causada por el virus de la viruela del simio (MPXV); sin embargo, ya no se limita a las regiones endémicas por lo que es un patógeno con alcance global, de importancia para la salud pública. Este virus es miembro del género Orthopoxvirus (OPXV) de la familia Poxviridae. Se trasmite al estar en contacto con una persona o animal infectado o con material contaminado por el virus. El cuadro clínico es semejante a la viruela humana, pero la MPX es menos contagiosa y grave, con una tasa de letalidad inferior y la linfoadenopatía es el signo más notable. El diagnóstico es clínico-epidemiológico y se utilizan diversas técnicas de laboratorio para confirmarlo. No existe un tratamiento específico, las medidas de sostén son individuales y dependen de la evolución de la enfermedad, se utilizan los antivirales para el tratamiento de las formas graves. Se demostró que las vacunas estándar contra la viruela inducen una fuerte protección cruzada contra MPXV. Se realiza una revisión bibliográfica actualizada del tema en cuestión.


Abstract Monkeypox (MPX) is a zoonotic tropical disease, endemic to some areas of Africa, caused by the monkeypox virus (MPXV), however, it is no longer limited to endemic regions and is therefore a pathogen with global reach, of public health importance. This virus is a member of the Orthopoxvirus (OPXV) genus of the Poxviridae family. It is transmitted by being in contact with an infected person or animal or with material contaminated by the virus. The clinical picture is similar to smallpox but MPX is less contagious and severe, with a lower case fatality rate, being lymphadenopathy the most prominent sign. The diagnosis is clinical-epidemiological and various laboratory techniques are used to confirm it. There is no specific treatment, support measures are individual and depend on the evolution of the disease, antivirals are used to treat severe forms. Standard smallpox vaccines have been shown to induce strong cross-protection against MPXV. An updated review of the subject in question is carried out.

6.
Braz. j. biol ; 82: e233523, 2022. tab
Article in English | LILACS, VETINDEX | ID: biblio-1153470

ABSTRACT

Microbiological studies of the sanitary and health status of psittacine birds that will be reintroduced is important in evaluating whether these animals act as carriers of pathogenic agents to other animals and humans. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a faster and more accurate method to identify bacteria than conventional microbiology methods. The aim of this study was to evaluate the health status of psittacines housed in captivity, by assessment of Gram-negative bacteria from fecal microbiota through MALDI- TOF MS identification. The results indicate high frequency of Gram-negative bacteria in feces (96.5%), especially from the Enterobacteriaceae family (88.7%). The most prevalent bacteria were Escherichia coli (39.0%), Proteus vulgaris (12.2%), Klebsiella spp. (12.1%) and Raoultella ornithinolytica (8.7%). Proteus hauseri, Citrobacter spp., Morganella morgannii, Providencia rettgeri, Enterobacter spp. and Escherichia hermannii were isolated with lower frequency. . All these agents are potentially pathogenic for parrots and can cause systemic infections in other animals and humans. These findings reinforce that MALDI- TOF MS proved to be a rapid and accurate method of identification of the microorganism and evaluation of the health status of psittacines, providing relevant data to assist decision-making regarding the sanitary protocols in wildlife centers, and possible future reintroduction of wild birds.


Estudos microbiológicos da sanidade de psitacídeos que serão reintroduzidos são importantes para avaliar se esses animais atuam como portadores de agentes patogênicos para outros animais e humanos. A espectrometria de massa por ionização/dessorção de matriz assistida por laser/tempo de vôo (MALDI-TOF MS) é um método mais rápido e preciso para identificar bactérias na comparação com métodos convencionais de microbiologia. O objetivo deste estudo foi avaliar o estado de saúde de psitacídeos cativos, identificando bactérias Gram-negativas da microbiota fecal por MALDI -TOF MS. Os resultados indicaram alta frequência de bactérias Gram-negativas nas fezes (96,5%), principalmente da família Enterobacteriaceae (88,7%). As mais prevalentes foram Escherichia coli (39,0%), Proteus vulgaris (12,2%), Klebsiella spp. (12,1%) e Raoultella ornithinolytica (8,7%). Proteus hauseri, Citrobacter spp., Morganella morgannii, Providencia rettgeri, Enterobacter spp. e Escherichia hermannii foram isolados com menor frequência. Todos esses agentes são potencialmente patogênicos para os papagaios e podem causar infecções sistêmicas em outros animais e seres humanos. Esses achados reforçam que o MALDI- TOF MS é um método rápido e preciso de identificação do microrganismo e avaliação do estado de saúde dos psitacídeos, fornecendo dados relevantes para auxiliar na tomada de decisões sobre os protocolos sanitários em centros de triagem de animais selvagens e sobre a possibilidade de reintrodução futura.


Subject(s)
Humans , Animals , Psittaciformes , Gram-Negative Bacteria , Proteus , Providencia , Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization , Enterobacteriaceae
7.
Rev. Univ. Ind. Santander, Salud ; 52(3): 295-309, Julio 8, 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1155628

ABSTRACT

Resumen Objetivo: describir los aspectos moleculares y celulares de la respuesta inmune frente a SARS-CoV-2; y las repercusiones clínicas, producto de mecanismos inmunes. Introducción: la aparición de una neumonía atípica en China, en diciembre de 2019, provocó un confinamiento global. El agente responsable de esta enfermedad fue nombrado por el Comité Internacional de Taxonomía de Virus como SARS-CoV-2, y la enfermedad que produce fue denominada COVID-19 por la OMS el 11 de febrero del 2020. Metodología: para este estudio descriptivo se indagó en la base de datos de Pubmed, Science, Nature, The Lancet, The New England Journal of Medicine, medRxiv y Google académico; cuyos descriptores utilizados fueron COVID-19, 2019-nCoV, SARS-CoV-2, linfocitos, anticuerpos e inmunidad; incluyendo en la revisión 130 estudios. Resultados: las manifestaciones clínicas más frecuentes que produce SARS-CoV-2 son: fiebre, tos seca y fatiga; siendo los individuos ancianos que presentan con mayor frecuencia complicaciones como el síndrome de distrés respiratorio agudo, arritmias, fallo cardíaco agudo y shock séptico. Se identificó descensos significativos de las células NK, linfocitos B, linfocitos T CD4+ y CD8+ en sangre periférica en pacientes con cuadros moderados y severos de COVID-19. Discusión: Las células NK y macrófagos se encargan de la contención y eliminación viral en las primeras etapas de la infección por SARSCoV-2. No está claro la relevancia de la respuesta humoral en la contención, y eliminación de SARS-CoV-2. La respuesta de linfocitos T citotóxicos es esencial para la completa resolución de la infección por SARS-CoV-2, ya que logran la eliminación de las células infectadas. No existe un tratamiento antiviral específico recomendado para COVID-19, y actualmente no existe vacuna disponible.


Abstract Objective: To describe the molecular and cellular aspects of the immune response against SARS-CoV-2 and the clinical repercussions resulting from inefficient immune mechanisms. Introduction: The emergence of an atypical pneumonia in China in December 2019 led to a global confinement. The agent responsible for this new disease was named SARS-CoV-2 by the International Committee on Taxonomy of viruses, and the disease it produces was named COVID-19 by the WHO on February 11, 2020. Methodology: For this descriptive study we researched the databases of Pubmed, Science, Nature, The Lancet, The New England Journal of Medicine, medRxiv and Google Scholar; which descriptors used were: COVID-19, 2019-nCoV, SARS-CoV-2, lymphocytes, antibodies and immunity; including 130 studies in the review. Results: The most common clinical manifestations produced by SARS-CoV-2 are: fever, dry cough and fatigue, being the elderly people who are mostly having complications such as acute respiratory distress syndrome, arrhythmias, acute heart failure and septic shock. Significant decreases in NK cells, B lymphocytes, CD4+ and CD8+ T lymphocytes were identified in peripheral blood in patients with moderate and severe COVID-19 conditions. Discussion: NK cells and macrophages are responsible for viral containment and elimination in the early stages of SARS-CoV-2 infection. The relevance of the humoral response in the containment and elimination of SARS-CoV-2 is unclear. The cytotoxic T lymphocyte response is essential for the complete resolution of SARS-CoV-2 infection, as they achieve the elimination of infected cells. There is no specific antiviral treatment recommended yet for COVID-19, and there is currently no vaccine available.


Subject(s)
Humans , Therapeutics , Coronavirus Infections , COVID-19 , Immunity , Signs and Symptoms , Lymphocytes , Coronavirus , Severe acute respiratory syndrome-related coronavirus , Infections
8.
Med. U.P.B ; 39(1): 4-12, 24 de febrero de 2020. tab, Ilus
Article in Spanish | COLNAL, LILACS | ID: biblio-1052254

ABSTRACT

Objetivo: caracterizar epidemiológicamente los eventos de infección asociada a la atención en salud en una clínica de alta complejidad en la ciudad de Medellín. Metodología: estudio observacional descriptivo retrospectivo, con una muestra de 1 712 pacientes que presentaron infección asociada a la atención en salud. A las variables de naturaleza cuantitativa se calcularon medidas de tendencia central, dispersión o de posición. Las variables de naturaleza cualitativa se presentan con frecuencias absolutas y relativas Resultados: la tasa global de infección fue de 4.3%; el 67.5% se presentó en adultos. En los últimos seis años se presentó una reducción constante de la tasa global de infección, del 2010 al 2015 del 35.4%. La infección de sitio operatorio es la más frecuente (29%), seguida de bacteriemia (21%), infección urinaria (18%) y neumonía (16%). La unidad de cuidados intensivos de adultos fue el servicio con mayor disminución en la tasa de infecciones, pasando del 15% en el 2012 al 8% en 2015. La Escherichia coli fue el microorganismo más aislado seguido de Staphylococcus spp. y Klebsiella spp. Conclusiones: los datos encontrados dejan ver que un adecuado programa de control de infecciones es esencial para el mejoramiento de la calidad de atención de los pacientes.


Objective: To make an epidemiological characterization of nosocomial infections in a high-complexity clinic in the city of Medellin. Methodology: Observational descriptive study with a sample of 1 712 patients, who presented nosocomial infection. The quantitative variables were analyzed by means of measures of central tendency, dispersion and position; in turn, the qualitative variables were presented with absolute and relative frequencies. Results: The rate infection was 4.3%; 67.5% occurred in adults. There was a continuous decrease in rate infection from 2010 to 2015 of 35.4%. Surgical site infection was the most common infection with 29%, followed by bacteremia (21%), urinary tract infection (18%) and pneumonia (16%). Adult intensive care unit was the service that showed a greater decrease in the rate of infections reducing from 15% in 2012 to 8% in 2015. Escherichia coli was the most isolated microorganism, followed by Staphylococcus aureus and Klebsiella sp. Conclusions: The data collected evidenced that a proper infection control program is essential in improving the quality of patient care.


Objetivo: caracterizar epidemiologicamente os eventos de infecção associada à atenção em saúde numa clínica de alta complexidade na cidade de Medellín. Metodologia: estudo observacional descritivo retrospectivo, com uma amostra de 1 712 pacientes que apresentaram infecção associada à atenção em saúde. Às variáveis de natureza quantitativa se calcularam medidas de tendência central, dispersão ou de posição. As variáveis de natureza qualitativa se apresentam com frequências absolutas e relativas. Resultados: a taxa global de infecção foi de 4.3%; 67.5% se apresentou em adultos. Nos últimos seis anos se apresentou uma redução constante da taxa global de infecção, de 2010 a 2015 de 35.4%. A infecção do lugar operatório é a mais frequente (29%), seguida de bacteriemia (21%), infecção urinária (18%) e pneumonia (16%). A unidade de tratamentos intensivos de adultos foi o serviço com maior diminuição na taxa de infecções, passando de 15% em 2012 a 8% em 2015. A Escherichia coli foi o microrganismo mais isolado seguido de Staphylococcus spp. e Klebsiella spp. Conclusões: os dados encontrados deixam ver que um adequado programa de controle de infecções é essencial para o melhoramento da qualidade de atenção dos pacientes.


Subject(s)
Humans , Cross Infection , Pneumonia , Staphylococcus , Surgical Wound Infection , Infection Control , Bacteremia , Escherichia coli , Quality Improvement , Intensive Care Units
9.
Enferm. univ ; 16(3): 313-321, jul.-sep. 2019. tab, graf
Article in Spanish | LILACS-Express | LILACS, BDENF | ID: biblio-1090113

ABSTRACT

Resumen El paso de guardia en enfermería es una actividad fundamental para dar continuidad al cuidado de los pacientes, se realiza como cumplimiento obligatorio de una tarea en el quehacer laboral. Objetivo Describir la producción científica publicada entre 2007-2017, referente a la temática de paso de guardia de enfermería en los servicios de urgencias. Metodología Se desarrolló una revisión sistemática en seis bases de datos, se incluyeron estudios en idiomas inglés, español y portugués que estuvieran publicados en revistas indexadas con acceso a texto completo. Se realizó un análisis crítico de cada uno de los artículos con las Herramientas CASPe y STROBE, los resultados se ordenaron en una matriz que facilitó la obtención de información y categorías. Resultados De un total de 430 artículos, se incluyeron a la investigación únicamente 19, de los cuales 17 están escritos en idioma inglés y dos en español. Después del análisis de los artículos seleccionados se estructuraron dos categorías: Características del paso de guardia y Estandarización del proceso. Conclusiones Las brechas en la comunicación se perfilan como uno de los principales aspectos a tener en cuenta, para mejorar el paso de guardia. El lugar más recomendable para que se lleve a cabo el proceso debe ser en la habitación del paciente y verificado por los dos equipos de enfermería. En la actualidad es necesario realizar investigaciones para mejorar el nivel de evidencia de los estudios.


Abstract Nursing shift handover is an obligatory and a fundamental activity to ensure continuity in the process of patient care. Objective To describe the scientific production published between 2007-2017 regarding nursing shift handover within medical emergency services. Methodology A systematic review was conducted on six databases. Articles with full texts written in English, Spanish, and Portuguese, and published in indexed journals were included. A critical analysis on each article was conducted using the Critical Appraisal Skills Programme spanish, and the Strengthening the Reporting of Observational Studies in Epidemiology tools. Articles were clustered in a matrix of categories. Results From a total of 430 possible articles, 19 were included for this study - 17 written in English and 2 written in Spanish. From the corresponding analysis, two categories were structured: Nursing Shift Handover Characteristics, and Process Standardization. Conclusions Communication gaps seem to be one of the main issues to address while improving the nursing shift handover process. The patient room should be the place for the shift handover, and this process must be acknowledged by both nursing teams.


Resumo A passagem de plantão em enfermagem é uma atividade fundamental para dar continuidade ao cuidado dos pacientes, realiza-se como cumprimento obrigatório de uma tarefa no trabalho laboral. Objetivo Descrever a produção científica publicada entre 2007-2017, referente à temática de passagem de plantão de enfermagem nos serviços de urgências. Metodologia Desenvolveu-se uma revisão sistemática em seis bases de dados, incluíram-se estudos em idiomas inglês, espanhol e português que estiveram publicados em revistas indexadas com acesso a texto completo. Realizou-se uma análise crítica de cada um dos artigos com as Ferramentas CASPe e STROBE, os resultados ordenaram-se em uma matriz que facilitou a obtenção de informação e categorias. Resultados De um total de 430 artigos, incluíram-se à pesquisa unicamente 19, dos quais 17 estão escritos em idioma inglês e dois em espanhol. Depois da análise dos artigos selecionados estruturaram-se duas categorias: Caraterísticas da passagem de plantão e Padronização do processo. Conclusões Os abismos na comunicação perfilam-se como um dos principais aspectos a ter em conta, para melhorar a passagem de plantão. O lugar mais recomendável para se efetuar o processo deve ser no quarto do paciente e verificado pelas duas equipes de enfermagem. Na atualidade é necessário realizar pesquisas para melhorar o nível de evidência dos estudos.

10.
Rev. Asoc. Argent. Ortop. Traumatol ; 84(3): 242-251, jun. 2019.
Article in Spanish | LILACS, BINACIS | ID: biblio-1020339

ABSTRACT

Introducción: Los defectos de cobertura en la pierna son un problema difícil de solucionar debido a las características propias de la región anatómica. Por ello, se han desarrollado distintas estrategias de reconstrucción, y los colgajos de perforante fasciocutáneos son los que se utilizan con más frecuencia. Objetivos: Presentar la alternativa terapéutica, describir la técnica quirúrgica, los resultados y las complicaciones del colgajo de perforante de la arteria tibial posterior para el tratamiento de defectos de cobertura en la pierna. Materiales y Métodos: Se realizó una revisión retrospectiva de los pacientes tratados con colgajo fasciocutáneo en la pierna y operados en nuestro Centro. Se analizaron variables demográficas preoperatorias. Se describen la técnica quirúrgica y las indicaciones en cada paciente. Se analizaron variables posoperatorias, como las complicaciones y la supervivencia del colgajo. Resultados: Se incluyeron 12 hombres tratados con colgajo de perforante de la arteria tibial posterior. El promedio de edad en el momento de la cirugía fue de 52 años (rango 29-77). El seguimiento máximo fue de 55 meses y el mínimo, de 5 meses (promedio 18). Hubo dos colgajos con sufrimiento transitorio, una falla parcial y una falla total. Conclusiones: El colgajo de perforante de la arteria tibial posterior ha de ser considerado una opción válida en el tratamiento de heridas de pequeño y mediano tamaño de la pierna. Provee de tejido similar en grosor, textura y color en el sitio receptor con buenos resultados clínicos y estéticos. Nivel de Evidencia: IV


Introduction: Coverage defects in the leg are a challenge due to the particulars of the anatomy in said area, different reconstruction strategies have been developed, being the fasciocutaneous perforator flaps the most frequently used. The aim of this paper is to discuss the therapeutic alternative and to describe the surgical technique, the results and the complications of the posterior tibial artery perforator flap (PTAPF) to treat coverage defects. Materials and Methods: We performed a retrospective review of patients treated with a fasciocutaneous flap. We analyzed preoperative demographic variables. The surgical technique and the indications in each patient are described. Finally, the postoperative variables, such as complications and flap survival, were analyzed. Results: Twelve patients (all male) treated with PTAPF were included. The average age at the time of surgery was 52 years (range: 29-77 years). The maximum follow-up was 55 months, with a minimum of 5 months (average: 18 months). There were two flaps with transient congestion that reverted spontaneously: one partial failure and one total failure. Conclusions: PTAPF should be considered a viable option for the treatment of small- and medium-sized leg wounds, since they provide similar tissue thickness, texture and color on the recipient site, achieving good clinical and cosmetic results. Level of Evidence: IV


Subject(s)
Adult , Surgical Flaps , Tibial Arteries/surgery , Leg Injuries/surgery , Treatment Outcome
11.
Rev. Asoc. Argent. Ortop. Traumatol ; 83(2): 76-84, jun. 2018. []
Article in Spanish | LILACS, BINACIS | ID: biblio-956421

ABSTRACT

Introducción: El principio de tratamiento de los defectos de cobertura lumbosacros se basa en el manejo del espacio muerto y la cobertura del defecto. El objetivo de este estudio es presentar la técnica quirúrgica, los resultados y las complicaciones de una serie de pacientes tratados con colgajo de recto anterior para defecto lumbosacro. Materiales y Métodos: Se efectuó una revisión retrospectiva durante un período de seis años. Se analizaron variables demográficas preoperatorias. Se describen la técnica quirúrgica y las complicaciones intraoperatorias. Se analizaron las variables posoperatorias, como complicaciones del sitio donante, complicaciones del sitio receptor y duración del colgajo. Resultados: Cinco pacientes cumplieron con los criterios de inclusión (edad promedio 50 años): cuatro con tumor sacro y una paciente con osteomielitis lumbosacra. El seguimiento promedio fue de 20 meses. El tamaño promedio de la pastilla cutánea fue de 8 x 13 cm. Entre las complicaciones, se registró una lesión del pedículo intraoperatoria (reparación microquirúrgica) y el óbito de un paciente. Se evidenció una infección con dehiscencia de la herida como complicación posoperatoria. No hubo complicaciones vasculares posoperatorias en los colgajos y todos permanecieron vitales durante el seguimiento. Conclusión: El colgajo de recto anterior ha de ser considerado una opción válida en el tratamiento de heridas con grandes defectos de partes blandas a nivel lumbosacro. Provee de suficiente volumen de piel y tejido muscular para la cobertura de dichos defectos. La técnica es relativamente sencilla sin necesidad de procedimiento microquirúrgico. Nivel de Evidencia: IV


Introduction: Treatment of soft tissue lumbosacral defects is based on dead space management and defect coverage. The aim of this study is to describe the surgical technique, results and complications of patients who underwent rectus abdominis flap for lumbosacral defects coverage. Methods: A six-year retrospective review was performed. Demographic characteristics are analyzed. Surgical technique and intra-operative complications are described. Postoperative variables, such as donor site complications, recipient site complications, and flap survival were also reported. Results: Five patients met the inclusion criteria (average age, 50 years). Four patients presented sacral tumor diagnosis and one patient had lumbosacral osteomyelitis. Mean follow-up was 20 months. Flap average size was 8 x 13 cm. Intraoperative complications were one pedicle injury (microsurgical repair) and the death of a patient. Regarding postoperative complications, one wound dehiscence was reported. None of the flaps suffered vascular complications and all remained vital throughout follow-up. Conclusion: Rectus abdominis flap should be considered a valid option in the management of large soft tissue lumbosacral defects. This flap provides sufficient skin volume and muscular tissue. Surgical technique is relatively simple with no need for microsurgical procedure. Level of Evidence: IV


Subject(s)
Adult , Surgical Flaps , Soft Tissue Injuries , Rectus Abdominis/surgery , Lumbosacral Region/surgery , Retrospective Studies , Follow-Up Studies , Intraoperative Complications
12.
Artrosc. (B. Aires) ; 25(1): 29-34, 2018. ilus
Article in Spanish | LILACS, BINACIS | ID: biblio-907455

ABSTRACT

En el manejo de pacientes embarazadas con fracturas se debe tener en cuenta no solo la vida de la madre sino del feto. Los cambios anatómicos y los cambios fisiológicos en el embarazo aumentan la complejidad del tratamiento. Presentamos el caso de una paciente femenina de 29 años cursando embarazo de 34 semanas quien presenta fractura del platillo tibial de su rodilla derecha Schatzker tipo 2 (AO 41 B3) tratada mediante reducción y osteosíntesis bajo asistencia artroscópica. Describimos un decálogo de tratamiento quirúrgico en pacientes embarazadas en el cual mencionamos los puntos esenciales a tener en cuenta al momento de planificar el tratamiento definitivo. Destacamos puntos como el posicionamiento de la paciente, la profilaxis antibiótica, el tipo de anestesia, la radiación tolerable y la tromboprofilaxis. El trabajo con un equipo médico multidisciplinario hizo posible realizar la cirugía controlando en forma segura a la paciente y el feto. La asistencia artroscópica permite tener visión directa de la superficie articular disminuyendo al mínimo la irradiación y logrando una reducción anatómica. Tipo de estudio: Reporte de caso. Nivel de evidencia: IV.


In the management of pregnant patients with fractures, both, the mother and the fetus risk of life must be taken into account. Anatomical and physiological changes in pregnancy increase the complexity of the treatment. We present the case of a 29-year-old female ongoing a 34-week pregnancy period. She presented tibial plateau fracture of her right knee classified as Schatzker type 2 (AO 41 B3). Treatment was done by reduction and osteosynthesis under arthroscopic assistance. We describe a decalogue of surgical treatment in pregnant patients in which we mention the essential points to take into account when planning the definitive treatment. We highlight points such as positioning of the patient, antibiotic prophylaxis, type of anesthesia, tolerable radiation and thromboprophylaxis. A safe surgical procedure with an optimal control of the patient and the fetus was possible by working with a multidisciplinary medical team. Arthroscopic assistance allows direct vision of the articular surface, minimizing irradiation and achieving anatomical reduction. Type of study: Case report. Level of evidence: IV.


Subject(s)
Adult , Arthroscopy/methods , Knee Injuries/surgery , Pregnancy , Tibial Fractures/surgery , Preoperative Care
13.
Arq. bras. med. vet. zootec. (Online) ; 69(5): 1206-1214, set.-out. 2017. ilus, tab, graf
Article in English | LILACS, VETINDEX | ID: biblio-878684

ABSTRACT

Renal ischemia can be associated with some urological procedures, such as renovascular surgery or kidney transplantation, that are often followed by acute renal failure. The aim of this study was to verify the E-cadherin and ß-catenin localization in canine kidney in different times of renal ischemia and reperfusion after chlorpromazine application. Twelve dogs were randomly distributed equally into two groups. GroupA with ischemia and reperfusion without chlorpromazine and groupB with ischemia and reperfusion treated by chlorpromazine. GroupB received intravenous chlorpromazine, 15 min before the artery obstruction, which lasted 1 hour. After this period, the clamps in the renal arteries were released and the organ remained in reperfusion for 2 hours. In each group, anti-E-cadherin and anti-ß-catenin antibodies were made in six tissue samples from renal parenchyma. E-cadherin and ß-catenin are differentially expressed in segments from cortex and medulla in dog's kidneys and the use of chlorpromazine did not alter the expression of both proteins. Occlusion of the left renal artery in dogs causes morphological alterations mainly in proximal convoluted tubules, beginning 30min after the start of ischemia and being aggravated after two hours of reperfusion. These results reveal that chlorpromazine did not change kidneys' histological aspect nor E-cadherin and ß-catenin expression.(AU)


A lesão renal isquêmica pode estar associada a procedimentos urológicos, tais como cirurgia renovascular, cirurgia renal extracorpórea ou transplante renal. Essa injúria, muitas vezes, é seguida de insuficiência renal aguda. O objetivo deste trabalho foi observar a localização da E-caderina e da ß-catenina em rim de cães, além de relacionar a expressão dessas proteínas das junções de aderência em diferentes tempos de isquemia e reperfusão com ou sem a aplicação de clorpromazina. Para tanto, foram utilizados 12 cães, distribuídos aleatoriamente em dois grupos de seis indivíduos: grupo A, com isquemia e reperfusão sem tratamento por clorpromazina, e o grupo B, com isquemia e reperfusão tratado por clorpromazina. No procedimento cirúrgico, foi realizada uma incisão paracostal esquerda para identificação e isolamento do rim esquerdo e da artéria renal esquerda. Após o isolamento da artéria, os animais de todos os grupos tiveram o vaso ocluído. Os animais do grupo B receberam clorpromazina via endovenosa, na dose de 5mg/kg, 15min antes da clampagem do vaso, que durou uma hora. Após este período, as artérias renais foram desobstruídas e os órgãos permaneceram em reperfusão por duas horas. Em cada grupo, foram extraídas seis amostras de parênquima renal, com utilização de agulha tru-cut, para marcação com anticorpos anti-E-caderina e anti-ß-catenina por meio de imunoistoquímica. E-caderina e ß-catenina são diferencialmente expressas em segmentos do córtex e da medula em rim de cães e o uso da clorpromazina não alterou a expressão das duas proteínas.(AU)


Subject(s)
Animals , Dogs , beta Catenin/analysis , Cadherins/analysis , Ischemia/veterinary , Kidney Tubular Necrosis, Acute/veterinary , Renal Insufficiency/veterinary , Cell Adhesion , Immunohistochemistry/veterinary , Kidney/anatomy & histology
14.
Rev. Asoc. Argent. Ortop. Traumatol ; 81(Supl): S23-S27, 2016. ilus, tab
Article in Spanish | LILACS, BINACIS | ID: biblio-831232

ABSTRACT

La espondilolistesis traumática del axis representa un 5% de las fracturas cervicales y es definida por una fractura de la pars interarticularis de la segunda vértebra cervical. El mecanismo de esta fractura, en general, implica fuerzas de hiperextensión. Los aspectos más importantes relacionados con el pronóstico y tratamiento son el compromiso discal C2-C3, el compromiso neurológico y la presencia de luxación facetaria. En relación con los tratamientos conservador o quirúrgico en patrones no desplazados, la cirugía podría determinar una recuperación precoz. Por otro lado, se han descrito buenos resultados con el uso del halo chaleco. Se presenta un caso de espondilolistesis traumática del axis tratado con osteosíntesis directa a través de un abordaje posterior en un paciente que rechazó el tratamiento conservador.


Traumatic spondylolisthesis of the axis accounts for 5% of all cervical spine fractures and is defined as a pars interarticularis fracture in the second cervical vertebra. Its mechanism usually involves hyperextension forces. The most important aspects related to prognosis and treatment are C2-C3 disk injury, neurological involvement, facetary dislocation and displacement. As regards the conservative or surgical management in non-displaced patterns, surgical management could result in an early recovery; however, there are good results with halo vest immobilization. We present a case with C2 direct crew osteosynthesis through a posterior approach in a patient who refused conservative treatment.


Subject(s)
Spondylolisthesis/surgery , Axis, Cervical Vertebra , Cervical Vertebrae/surgery , Cervical Vertebrae/injuries
15.
Arq. bras. med. vet. zootec ; 65(6): 1729-1737, Dec. 2013. ilus, graf, tab
Article in English | LILACS | ID: lil-696855

ABSTRACT

The objective of this study was to evaluate the clinical and histological effects of occluding the nasolacrimal ducts and points of rabbits. For this study, 20 adult New Zealand rabbits, both males and females, weighing 3.2±0.4kg were allocated into two groups for n-butyl-cyanoacrylate occlusion (GB, n=10) or 2-octyl-cyanoacrylate occlusion (GO, n=10). The contralateral eyes served as the controls. The persistence of tears was evaluated daily using the Schirmer I test. Discomfort, eye discharge, epiphora, and conjunctival hyperemia were assessed prior to the procedure (T0) and during the 14 subsequent days (T1-T14). On days seven and 14, five animals from each group were euthanized, and their nasolacrimal ducts were collected, processed and analyzed by histology. In the GB group, the Schirmer test values differed from that at T0 at all of the subsequent time points, whereas there was no difference in the values observed from the GO group. Compared with the corresponding controls, the GO and GB groups differed significantly at almost all of the time points. When comparing the treatment groups, differences were found at T6, T7, T9, T10, T11, T12 and T14, with higher Schirmer values in the GB group. Epiphora was observed in the GB group from T1 to T8 and in the GO group from T1 to T6. Within seven days post-occlusion, histology revealed a moderate foreign body reaction, with marked necrosis and sloughing of the canalicular epithelium, in the GO group, which was absent at day 14. In the GB group, a marked inflammatory reaction and a mild foreign body reaction were found at day seven, and the foreign body reaction was prevalent at day 14. This study demonstrated that both adhesives were effective in obstructing the nasolacrimal ducts and points of rabbits and that their application and handling are easy and free of complications. However, both adhesives promoted inflammatory and foreign body reactions that evolved to repair and regeneration at day 14 of evaluation.


Avaliaram-se os efeitos clínicos e histológicos da oclusão do ponto e do duto nasolacrimais de coelhos. Para isso, utilizaram-se 20 coelhos adultos da raça Nova Zelândia, machos e fêmeas, com peso de 3,2±0,4kg, distribuídos em dois grupos: oclusão com n-butil cianoacrilato (GB, n=10) e oclusão com 2-octil cianoacrilato (GO, n=10). Os olhos contralaterais foram utilizados como controle. A permanência da lágrima foi avaliada diariamente pelo teste de Schirmer I. Foram avaliados o desconforto, secreção ocular, epífora e hiperemia conjuntival, previamente ao procedimento (T0) e durante 14 dias (T1-T14). Aos sete e aos 14 dias, cinco animais de cada grupo foram submetidos à eutanásia, e os dutos nasolacrimais, colhidos, processados e analisados à histologia. Em GB, os valores de Schirmer diferiram de T0 em todos os momentos; em GO não houve diferença. Na comparação com o respectivo controle, GB e GO diferiram significativamente em quase todos os momentos. Ao compararem-se os tratamentos, houve diferença em T6, T7, T9, T10, T11, T12 e T14, sendo os valores de Schirmer superiores em GB. Epífora esteve presente em GB de T1 a T8 e em GO de T1 a T6. À histologia, em GO, aos sete dias, notou-se moderada reação de corpo estranho com marcante necrose e descamação do epitélio canalicular; tais alterações estiveram ausentes aos 14 dias. Em GB, verificou-se, aos sete dias, acentuada reação inflamatória e discreta reação de corpo estranho; aos 14 dias, houve predomínio da reação de corpo estranho. Concluiu-se que ambos os adesivos foram eficazes na obstrução do ponto e do duto nasolacrimais de coelhos, sendo sua aplicação e manuseio fáceis e livres de intercorrências e ambos promoveram reação inflamatória e de corpo estranho que evoluíram para reparação e regeneração aos 14 dias de avaliação.


Subject(s)
Animals , Keratoconjunctivitis/pathology , Nasolacrimal Duct/anatomy & histology , Histology , Tears/physiology , Eye/anatomy & histology , Rabbits/classification
16.
Rev. colomb. cardiol ; 20(3): 172-175, mayo-jun. 2013. ilus, tab
Article in Spanish | LILACS, COLNAL | ID: lil-683028

ABSTRACT

Se expone una serie de casos de pacientes con hiperostosis reactiva secundaria a la utilización prolongada de prostaglandinas en el contexto de cardiopatías congénitas complejas, que por su condición hemodinámica requirieron mantener el cortocircuito vascular de izquierda a derecha para su supervivencia. Se muestran las características imaginológicas típicas en radiografía convencional y se analizan los detalles fisiopatológicos y los diagnósticos diferenciales.


We present a series of cases of patients with reactive hyperostosis secondary to prolonged use of prostaglandins in the context of complex congenital heart disease, which due to its hemodynamic condition required to maintain the left to right vascular shunt for their survival. We show the typical imaginological characteristics in conventional radiography and discuss the pathophysiological details and the differential diagnoses.


Subject(s)
Humans , Male , Infant , Prostaglandins , Heart Defects, Congenital , Therapeutics , Radiography , Diagnosis, Differential , Hemodynamics
17.
Mem. Inst. Invest. Cienc. Salud (Impr.) ; 10(1): 24-35, jun. 2012. ilus
Article in Spanish | LILACS, BDNPAR | ID: lil-663636

ABSTRACT

La neumonía adquirida en la comunidad (NAC) es una causa relevante de morbilidad y mortalidad. Los métodos convencionales fracasan en la detección de Mycoplasma pneumoniae, Chlamydophila pneumoniae y Legionella pneumophila. Estas bacterias pueden generar procesos infecciosos crónicos y no responden a ciertos antibióticos empleados en el tratamiento empírico de la NAC. Nuestro objetivo fue detectar de forma simultánea, mediante métodos moleculares, M. pneumoniae, C. pneumoniae y L. pneumophila en muestras respiratorias de pacientes con NAC, y describir los gérmenes comunes aislados por métodos microbiológicos convencionales. Estudio observacional descriptivo de corte trasverso realizado en el año 2011, en el que se analizaron 60 muestras respiratorias provenientes de pacientes con NAC atendidos en el INERAM (Instituto de Enfermedades Respiratorias y del Ambiente). Para la PCR múltiple se emplearon primers específicos para genes de los tres microorganismos citados. El protocolo de estudio fue aprobado por los comités científico y ético del IICS y se mantuvieron en estricta confidencialidad los datos personales de los pacientes. La PCR múltiple permitió la amplificación de los genes específicos de estos microorganismos con límites de sensibilidad comprendidos entre 0,05 y 0,001 ng/µL de ADN. M. pneumoniae y C. pneumoniae estuvieron presentes respectivamente en el 18,3% y 1,7% del total de muestras analizadas. No se detectó la presencia de L. pneumophila. Los gérmenes comunes más frecuentemente aislados fueron estreptococos del grupo viridans y Candida spp.La técnica de PCR múltiple permitió detectar M. pneumoniae, C. pneumoniae y L. pneumophila, siendo el primero de los tres el más frecuentemente detectado en pacientes con NAC


Subject(s)
Chlamydophila pneumoniae , Legionnaires' Disease , Mycoplasma pneumoniae
18.
Braz. j. med. biol. res ; 44(3): 240-244, Mar. 2011. tab
Article in English | LILACS | ID: lil-576075

ABSTRACT

Common variants of the transcription factor 7-like 2 (TCF7L2) gene have been found to be associated with type 2 diabetes in different ethnic groups. The Japanese-Brazilian population has one of the highest prevalence rates of diabetes. Therefore, the aim of the present study was to assess whether two single-nucleotide polymorphisms (SNPs) of TCF7L2, rs7903146 and rs12255372, could predict the development of glucose intolerance in Japanese-Brazilians. In a population-based 7-year prospective study, we genotyped 222 individuals (72 males and 150 females, aged 56.2 ± 10.5 years) with normal glucose tolerance at baseline. In the study population, we found that the minor allele frequency was 0.05 for SNP rs7903146 and 0.03 for SNP rs12255372. No significant allele or genotype association with glucose intolerance incidence was found for either SNP. Haplotypes were constructed with these two SNPs and three haplotypes were defined: CG (frequency: 0.94), TT (frequency = 0.027) and TG (frequency = 0.026). None of the haplotypes provided evidence for association with the incidence of glucose intolerance. Despite no associations between incidence of glucose intolerance and SNPs of the TCF7L2 gene in Japanese-Brazilians, we found that carriers of the CT genotype for rs7903146 had significantly lower insulin levels 2 h after a 75-g glucose load than carriers of the CC genotype. In conclusion, in Japanese-Brazilians, a population with a high prevalence of type 2 diabetes, common TCF7L2 variants did not make major contributions to the incidence of glucose tolerance abnormalities.


Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Glucose Intolerance/genetics , Polymorphism, Single Nucleotide , /genetics , Asian People , Brazil , Gene Frequency , Genetic Predisposition to Disease , Genotype , Glucose Intolerance/ethnology , Incidence , Prospective Studies
19.
Braz. j. med. biol. res ; 43(7): 645-650, July 2010. ilus, graf
Article in English | LILACS | ID: lil-550735

ABSTRACT

Leukotrienes are reported to be potent proinflammatory mediators that play a role in the development of several inflammatory diseases such as asthma, rheumatoid arthritis and periodontal disease. Leukotrienes have also been associated with protection against infectious diseases. However, the role of leukotrienes in Mycobacterium tuberculosis infection is not understood. To answer this question, we studied the role of leukotrienes in the protective immune response conferred by prime-boost heterologous immunization against tuberculosis. We immunized BALB/c mice (4-11/group) with subcutaneous BCG vaccine (1 x 10(5) M. bovis BCG) (prime) followed by intramuscular DNA-HSP65 vaccine (100 µg) (boost). During the 30 days following the challenge, the animals were treated by gavage daily with MK-886 (5 mg·kg-1·day-1) to inhibit leukotriene synthesis. We showed that MK-886-treated mice were more susceptible to M. tuberculosis infection by counting the number of M. tuberculosis colony-forming units in lungs. The histopathological analysis showed an impaired influx of leukocytes to the lungs of MK-886-treated mice after infection, confirming the involvement of leukotrienes in the protective immune response against experimental tuberculosis. However, prime-boost-immunized mice treated with MK-886 remained protected after challenge with M. tuberculosis, suggesting that leukotrienes are not required for the protective effect elicited by immunization. Protection against M. tuberculosis challenge achieved by prime-boost immunization in the absence of leukotrienes was accompanied by an increase in IL-17 production in the lungs of these animals, as measured by ELISA. Therefore, these data suggest that the production of IL-17 in MK-886-treated, immunized mice could contribute to the generation of a protective immune response after infection with M. tuberculosis.


Subject(s)
Animals , Female , Mice , Bacterial Proteins/immunology , /immunology , Leukocytes/immunology , Leukotrienes/biosynthesis , Tuberculosis, Pulmonary/prevention & control , Vaccines, DNA/immunology , BCG Vaccine/administration & dosage , BCG Vaccine/immunology , Bacterial Proteins/administration & dosage , Cell Movement , /administration & dosage , Cytokines/biosynthesis , Immunization, Secondary , Indoles/pharmacology , Leukotriene Antagonists/pharmacology , Leukotrienes/agonists , Lung/immunology , Lung/microbiology , Lung/pathology , Mice, Inbred BALB C , Tuberculosis, Pulmonary/immunology , Tuberculosis, Pulmonary/pathology , Vaccines, DNA/administration & dosage
20.
Article in Spanish | LILACS, BDNPAR | ID: biblio-1342434

ABSTRACT

Mycobacterium abscessus es una de las micobacterias de crecimiento rápido asociadas a infecciones localizadas de heridas post traumáticas y quirúrgicas, infecciones crónicas pulmonares e infecciones cutáneas diseminadas en pacientes inmunosuprimidos. Raramente han sido descritos infecciones en región parotídea por micobacterias de crecimiento rápido. Aquí se reporta el caso de una infección en lóbulo superficial de la glándula parótida de pacientesin compromiso inmune, sin cirugías previas ni traumas aparentes, causado por Mycobacterium abscessus. Estas micobacterias deben ser consideradas en el momento de realizar el diagnóstico tanto clínico como laboratorial, ya que son bacterias emergentes y pueden presentarse de manera inusual, de modo a no demorar el diagnóstico del agente etiológico, debido a que requieren prolongada antibioticoterapia y son bastante resistentes a los antibióticos, especialmente el M. abscessus, que es una de las más resistentes


Mycobacterium abscessus is one of the fast-growing mycobacteria associated to localized infections of post-traumatic injuries, surgical wounds, pulmonary chronic infections and disseminated cutaneous infections in immunosupressed patients. Fast-growing mycobacteria infections of the parotid region have been rarely described. We report the case of a Mycobacterium abscessus infection of the superficial lobe of the parotid gland without immune compromise, previous surgeries or apparent trauma. Thesemycobacteria should be considered at the time of clinical and laboratory diagnosis, as they are emerging bacteria and could present in an unusual manner, in order not to delay the diagnosis of the etiological agent because they require long antibiotic therapy and are pretty resistant to antibiotics specially M. abscessus which is one of the most resistant


Subject(s)
Humans , Female , Aged , Parotid Region , Mycobacterium Infections, Nontuberculous , Mycobacterium abscessus , Mycobacterium
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