ABSTRACT
OBJECTIVE@#To evaluate the effectiveness of glucocorticoid in the management of olfaction in patients with chronic rhinosinusitis accompanied with nasal polyposis.@*METHOD@#The published studies of the effectiveness of glucocorticoid in the management of chronic rhinosinusitis with nasal polyposis were searched in the Medline, Cochrane, EMBASE, Springer and CNKI databases(from the date of establishment of the databases to December 2014). The trails selection based on inclusion criteria and the quality of the included studies was assessed and meta-analysis was performed with RevMan 5. 3 software.@*RESULT@#A total of 5 trials involving 325 patients were included. The Meta-analysis showed that oral glucocorticoid showed more significant improvement in subjective olfaction scores compared to placebo [SMD = -2.22, 95% CI (-3.94 - -0. 49), P 0.05], [SMD = 0.28, 95% CI (-0.08-0.64) P > 0.05].@*CONCLUSION@#According to current evidence, oral glucocorticoid can significantly improve subjective and objective olfaction among patients with CRSwNP, but nasal glucocorticoid cannot improve subjective or objective olfaction dysfunction.
Subject(s)
Humans , Chronic Disease , Clinical Trials as Topic , Glucocorticoids , Therapeutic Uses , Nasal Polyps , Drug Therapy , Sinusitis , Drug Therapy , SmellABSTRACT
OBJECTIVE@#To investigate the expression and clinical significance of BUB1 protein in laryngeal squa mous cell carcinoma (LSCC) tissues.@*METHOD@#The expression of BUB1 protein was measured by immunohistochemistry (EliVision two steps) in 55 cases of LSCC tissues,30 cases of adjacent normal laryngeal mucosa tissues, the relationship of BUB1 expression with clinical pathologic factors in LSCC was also analyzed.@*RESULT@#The positive rate of BUB1 protein in LSCC tissues (50.9%, 28/55) was significantly lower than that in adjacent normal laryngeal mucosa tissues (83.3%, 25/30), P 0.05, respectively).@*CONCLUSION@#The low expresssion of BUB1 protein is closely related to the tumorigenesis and development of LSCC, and can be a molecular marker for prognosticating metastasis and prognosis of LSCC.
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Carcinoma, Squamous Cell , Metabolism , Pathology , Immunohistochemistry , Laryngeal Mucosa , Metabolism , Laryngeal Neoplasms , Metabolism , Pathology , Lymphatic Metastasis , Neoplasm Proteins , Metabolism , Prognosis , Protein Serine-Threonine Kinases , MetabolismABSTRACT
OBJECTIVE@#To evaluate the curative effect of endoscopic surgery (ESS) in the treatment of inverted papillomas in the nasal cavity and paranasal sinus.@*METHOD@#We report on 16 clinicopathologic cases of inverted papilloma. After preoperative endoscopic examination and CT screening, endoscopic sinus surgery was performed under general anesthesia.@*RESULT@#The follow-up period ranged between one year to two years. Recurrence was observed in 2 cases.@*CONCLUSION@#The nasal endoscopy is a better method for treating Krouse I-II stage nasal inverted papilloma. The advantages of endoscopic surgery include clear visual field, less bleeding, limited reoccurrence, and avoidance of facial incision.