Synthesis and some reactions of 4-[2-Alkyl-2-arylhydrazono]-2-phenyloxazol-5-o ne derivatives

A series of new 4-[2-alkyl-2-arylhydrazono]-2-phenyloxazol-5-ones derivatives 2a-d were synthesized by reaction of the oxazolones 1a, b with methyl and ethyl iodides. On the other hand, trial to alkylate 1a with methyl bromoacetate or phenacyl bromide afforded the triazine 3 and pyridinone 7, respectively. The reaction of 2a, b with ammonia or primary aromatic amines or hydrazines gave the acyclic amides 8a, b, 10a-d and hydrazides 12a-d, respectively. Cyclization of 8a, b and 10a, b gave imidazoles 9a, b, and 11a, b. While cyclization of 12a-d afforded triazines 13a, b and 14a, b, respectively

Alkylation reaction and Michael condensation of 3 aroyl acrylic acids

It is reported that when Beta [3,4-dichloro]-benzoyl acrylic acid was treated with aromatic hydrocarbons and aluminum chloride, addition occurred alpha to carboxyl group. In this study this method has been applied to Beta [p-phenyl]-benzoyl acrylic acid la, to augment the reactivity of the aroyl acrylic acids to react as alpha, Beta-unsaturated ketones rather than alpha, Beta-unsaturated acids in which the polar factor increases. The acid la undergoes addition reaction with p-xylene under Friedel Crafts conditions to give the corresponding alpha-[2, 5-dimethyl]-phenyl-Beta-[p-phenyl]-benzoyl propionic acid [II]. The structure of the resultant acid II was derived from its spectral data. IR spectrum showed bands due to ketonic C=O [1680], carboxylic CO [1710] and OH [3300-3000]. The PMR spectrum [CDC1[3]] showed signals at 2:29 and 2:36 [6H, s, of Ar-CH[3]], 2.80-3-50 [dxd, 2H of non equivalent CH[2]], 3-95-4-3 [m, IH of >CH-] and 7-7-8 [m, 12H of Ar-H]

Alkylation of indole with Baroylacrylic acids and some studies on the alkylated products

A large number of pyridazinones are reported to exhibit insecticidal and bactericidal activities. This prompted us to synthesise a new series of pyridazinones through the alkylation of indole with Beta-aroylacrylic acids followed by cyclization with hydiazines to the corresponding pyridazinone, the synthesis of various compounds prepared are outlined in Schemes 1-6