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1.
Utility of beige mouse in leprosy research.
Gangadharam, P R; Dhople, A M.
Indian J Lepr ; 1992 Oct-Dec; 64(4): 475-81
Article in English | IMSEAR | ID: sea-54568

ABSTRACT

Dissemination of M. leprae to visceral organs is seen by four months onwards only in beige (C57BL/6/bgj) but not BALB/c mice following intravenous or intraperitoneal infections. Inoculation of the beige mouse derived M. leprae showed all the characteristics of M. leprae, including growth pattern in the foot-pads of BALB/c mice. M. leprae inoculated into foot-pads of beige mice multiplied faster than those in the foot-pads of BALB/c mice. The possibility of using beige mouse in chemotherapeutic studies in leprosy is discussed.


Subject(s)
Animals , Disease Models, Animal , Female , Leprosy/microbiology , Liver/microbiology , Mice , Mice, Inbred BALB C , Mice, Inbred C57BL/microbiology , Mycobacterium leprae/growth & development , Spleen/microbiology
2.
Direct test for determining sensitivity of M. tuberculosis to streptomycin.
Devaki, V; Gangadharam, P R; Nair, N G.
Article in English | IMSEAR | ID: sea-20021

Subject(s)
Humans , Methods , Microbial Sensitivity Tests , Mycobacterium tuberculosis/drug effects , Sputum/microbiology , Streptomycin/pharmacology , Time Factors
3.
A sputum swab culture method for tubercle bacilli using Cetrimide, compared with two other swab culture methods and the concentration culture method.
Joseph, S; Nair, N G; Gangadharam, P R.
Article in English | IMSEAR | ID: sea-17574

Subject(s)
Culture Media , Indicators and Reagents , Methods , Mycobacterium/isolation & purification , Oxalates , Quaternary Ammonium Compounds , Sputum/microbiology , Sulfuric Acids
4.
Direct sensitivity test for isoniazid.
Devaki, V; Mohan, K; Gangadharam, P R.
Article in English | IMSEAR | ID: sea-21436

Subject(s)
Culture Media , Humans , Isoniazid/pharmacology , Methods , Microbial Sensitivity Tests , Mycobacterium tuberculosis/drug effects
5.
Effect of storage for three months at different temperatures on the sensitivity to streptomycin and isoniazid of cultures of tubercle bacilli.
Devaki, V; Mohan, K; Gangadharam, P R.
Article in English | IMSEAR | ID: sea-20455

Subject(s)
Bacteriological Techniques , Drug Resistance, Microbial , Isoniazid/pharmacology , Mycobacterium tuberculosis/drug effects , Streptomycin/pharmacology , Temperature , Time Factors
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