ABSTRACT
Background: Reactive oxygen species released on stimulation by periodontal pathogens cause oxidation of biomolecules and play significant role in periodontal disease pathogenesis. Aim: This study aimed to evaluate the levels of oxidative by?products malondialdehyde (MDA) and 8?hydroxy deoxyguanosine (8?OHdG) as biomarkers in chronic periodontitis patients compared to healthy as well as before and after nonsurgical periodontal therapy. The correlation between biomarkers and clinical attachment level was also evaluated. Settings and Design: A total of 112 subjects were included in this study. The subjects were divided into two groups (Group I included 56 healthy subjects and Group II constituted 56 chronic periodontitis patients) on the basis of clinical periodontal parameters. Materials and Methods: Group I subjects received no treatment and were evaluated once only for clinical and oxidative stress biomarker parameters. Nonsurgical periodontal therapy was carried out in Group II patients and they were evaluated at baseline and 3 months after therapy. Results: Both salivary and serum levels of MDA and 8?OHdG were found to be increased in chronic periodontitis patients as compared to healthy subjects. After nonsurgical periodontal therapy, the levels of MDA and 8?OHdG significantly reduced. Linear correlation between clinical attachment level and oxidative stress parameters was found to be positive and highly significant. Conclusion: It can be concluded that periodontal therapy is effective in improving the oxidative stress condition.
ABSTRACT
Introduction: Cardio vascular disease (CVD) is the leadingcause of mortality and morbidity in diabetes mellitus (DM)contributing to 65% of all deaths with diabetic complications.Detection of the deranged lipid profile in the pre-diabeticstate has been shown to be associated with increased risk ofatherosclerosis. This study was planned to compare changesin lipid profiles of patients with pre-diabetes and diabetes inpopulation of Lucknow, India.Material and Methods: A total of 236 cases (115 Pre-diabeticand 121 Diabetic) who fulfilled the inclusion and exclusioncriteria of this study were enrolled. The patients were evaluatedfor serum fasting blood sugar (FBS), post prandial blood sugar(PPBS), HbA1c, total cholesterol (TC), triglycerides (TGs), inthe two groups. The results were statistically analysed usingSPSS statistical package version 20.Results: The mean value of total cholesterol were179.21±8.12mg/dl in pre-diabetics and 182.31±7.99mg/dl indiabetics, which was statistically not significant (p=0.003).The mean value of triglyceride in pre-diabetics was134.43±5.21mg/dl and in diabetics 167.87±7.37mg/dl whichis statistically significant (p<0.001).Conclusion: The altered lipid profile in pre-diabetics signifiesan increased susceptibility to CVD in the long run. Therefore,screening of pre-diabetics for dyslipidemia is recommendedto arrest the development of cardiovascular complications.