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Acta gastroenterol. latinoam ; 30(3): 151-4, jul. 2000. tab, graf
Article in Spanish | LILACS | ID: lil-269917

ABSTRACT

The aim of the present paper is to establish the possible role of serum TNF in the pathophysiology of three experimental models of liver injury: paracetamol intoxication, cholestasis followed by paracetamol intoxication and cholestasis. We concluded that under our experimental conditions the serum TNF-alpha levels were not responsible for the inflammatory phenomena described in our previous paper as apopt.


Subject(s)
Animals , Male , Rats , Acetaminophen/toxicity , Analgesics, Non-Narcotic/toxicity , Cholestasis/chemically induced , Kidney Diseases/physiopathology , Tumor Necrosis Factor-alpha/physiology , Acetaminophen/blood , Alanine Transaminase/blood , Analgesics, Non-Narcotic/blood , Analysis of Variance , Aspartate Aminotransferases/blood , Bilirubin/blood , Bilirubin/metabolism , Case-Control Studies , Cholestasis/physiopathology , Liver/drug effects , Rats, Wistar , Tumor Necrosis Factor-alpha/chemistry
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