Antimicrobial Activity of Eucalyptus Camaldulensis And Calotropis Gigantea Against Various Pathogens.

Eucalyptus camaldulensis and Calotropis gigantea are common weed and known for various medicinal properties. The aim of the present study was to screen leaves of Eucalyptus camaldulensis and roots of Calotropis gigantea for the antimicrobial activity against clinical isolates of bacteria. The leaf and root extract were obtained by the organic solvents methanol. The methanolic extract of the E. camaldulensis and C. gigantea was studied for its antagonistic activity against Escherichia coli, Staphylococcus aureus, Proteus vulgaris, Salmonella typhi, Pseudomonas aeruginosa, Bacillus subtilis, Klebsiella pneumonia, Salmonella paratyphi. The results obtained from this study inferred that the leaf extract of Eucalyptus camaldulensis was effectively inhibited the growth of test organism, while Calotropis gigantae did not show the activity which is in combination with E. camaldulensis shows the more activity against all pathogens.

Facile synthesis of chelating bis ligands: spectroscopic, physicochemical and biological studies.

Seven bis-ligands of carbamides were synthesized and characterized on the basis of elemental analysis, Infrared spectroscopy, 1H NMR, mass spectra and UV-Visible studies. These bis-ligands were synthesized by condensation method, of acidic dichloride with 4-methoxyphenylcarbamide (4-MPC) in stoichiometric ratio of 1:2 respectively. It were found that, the behaviour of bis-ligands acting as chelating agents (chelators), therefore these were comparatively interpreted on the basis of physicochemical properties such as viscosity, surface tension, conductivity, pH and solubility. The antimicrobial activities of chelating ligands also have been studied. The results were revealing that, the activities of newly synthesized chelating ligands were found to be higher than its parent’s compound. The aromatic chelating compounds shows more activity in all physicochemical properties as compare to aliphatic chelators. The nanoparticle sizes of chelating ligands were significantly identified by scanning electron microscopy (SEM) and morphological result of each chelating compound were found totally different.

Microwave assisted synthesis and biological evaluation of 2-aryl/heteryl-3-aryloxy/heteryloxy-4h-chromones (4-oxo-2-aryl/heteryl-4h-chromen-3-yl-carboxylate).

2-Aryl/heteryl-3-aryloxy/heteryloxy-4H-chromones 5 have been synthesized through a series of reactions starting from phenols under microwave irradiation. This process is an effective alternative to the traditional thermal heating method. The yields are excellent and the reaction time is in a few minutes. These compounds have been characterized on the basis of IR, 1H NMR, 13C NMR and Mass spectrometry and evaluated for antibacterial activity.