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Indian J Physiol Pharmacol ; 1975 Jul-Sep; 19(3): 152-6
Article in English | IMSEAR | ID: sea-106336

ABSTRACT

In rats, propranolol potentiated alcohol and pentobarbitone hypnosis, but not barbital sleeping time, indicating enzyme inhibition as a possible mechanism of potentiation. Propranolol showed anticonvulsant effect on normal and reserpine treated rats by MES test, but showed dose related lowering of MET. Probable mechanisms are discussed.


Subject(s)
Animals , Barbital/pharmacology , Brain Chemistry/drug effects , Drug Synergism , Electroshock , Ethanol/pharmacology , Male , Pentobarbital/pharmacology , Phenoxybenzamine/pharmacology , Propranolol/pharmacology , Rats , Reserpine/antagonists & inhibitors , Seizures/prevention & control , Serotonin/analysis , Sleep/drug effects
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