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1.
China Journal of Chinese Materia Medica ; (24): 1769-1771, 2011.
Article in Chinese | WPRIM | ID: wpr-354127

ABSTRACT

Six compounds were isolated from the roots of Pithecellobium lucidum by various chromatograhic techniques such as column chromatography on silica gel and Sephadex LH-20, and preparative HPLC, and their structures were elucidated as julibroside A2 (1), 3-[ (2-acetamido-2-deoxy-beta-D-glucopyranosyl) oxy] -16alpha-hydroxyolean-12-en-28-oic acid (2), galloyl acid (3), ethyl gallate (4), (+)-catechin (5), (-)-gallocatechin gallate (6) on the basis of spectrascopic data analysis. Compounds 1-6 were isolated from Pithecellobium lucidum for the first time. Compound 2 showed selective cytoxic activity against the human cell lines A2780 with an IC50 value of 1.72 micromol x L(-1).


Subject(s)
Humans , Catechin , Chemistry , Toxicity , Cell Line , Fabaceae , Chemistry , Gallic Acid , Chemistry , Toxicity , Inhibitory Concentration 50 , Oleanolic Acid , Chemistry , Plant Extracts , Chemistry , Toxicity , Plant Roots , Chemistry , Plants, Medicinal , Chemistry , Saponins , Chemistry , Toxicity , Triterpenes , Chemistry , Toxicity
2.
China Journal of Chinese Materia Medica ; (24): 1421-1424, 2010.
Article in Chinese | WPRIM | ID: wpr-328107

ABSTRACT

The chemical constituents from the stem barks of Vernonia cumingiana were investigated. Various chromatographic techniques such as silica gel chromatography, Sephadex LH-20, ODS column chromatography and HPLC were used to isolate and purify the constituents. The structures were elucidated by spectral methods. Twelve compounds were isolated from the 95% ethanol extract and their structures were elucidated as methyl 3,5-dicaffeoylquinate (1), methyl 3,4-dicaffeoylquinate (2), ethyl 3,4-dicaffeoylquinate (3), methyl 3,4,5-tricaffeoylquinate (4), stigmasterol (5), alpha-spinasterol (6), beta-sitosterol (7), 24-methylene-lanosta-9 (11)-en-3beta-acetate (8), ethyl gallate (9), di-n-butyl-phthalate (10), stearic acid (11) and palmitic acid (12). Compounds 1-12 were isolated from this plant for the first time.


Subject(s)
Plant Bark , Chemistry , Plant Extracts , Plant Stems , Chemistry , Vernonia , Chemistry
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