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Objective To analyze the clinical effect of combination therapy of somatidine on colorectal cancer with intestinal obstruction. Methods 120 patients with colorectal cancer complicated with intestinal obstruction who were treated with Yujiang County Hospital of Zhejiang Province from November 2016 to May 2017 were selected as the subjects of this study and divided into observation group by dynamic random color ball extraction method And control group. The rats in the control group were given stage I colonic resection and anastomosis. The observation group was treated with somatanine combined with stage I colonic resection and anastomosis. The differences of the indexes and complication were compared between the two groups. Results There was no significant difference in the operation time between the two groups (3.01 ± 0.41) days and the hospitalization time (10.11 ± 1.21) days in the observation group, and the time of operation was significantly higher than that of the control group (5.41 ± 0.84) days, the hospitalization time was (16.33 ± 2.05) days, the number of complications occurred in 10 cases, the difference was more than that in the control group Significantly(P<0.05). Conclusion Si Tanning combined with surgical treatment of colorectal cancer with intestinal obstruction has a certain value.
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Objective To investigate the relationship between BRCA1 protein expression in lung cancer tissues and the effect of gemcitabine and Cisplatin based chemotherapy.Methods 80 cases of squamous cell carcinoma confirmed by pathology from May 2013 to May 2015 were selected, and treated with gemcitabine plus cisplatin chemotherapy and Ginseng and Astragalus assisted theropy.BRCA1 protein expression of all patients were detected, and relationship between the effect of chemotherapy and prognosis of patients with BRCA1 protein expression in lung cancer tissues were studied.Results In 80 cases, BRCA1 protein was positive in 40 cases, 40 cases were negative, CR 5 patients, PR 6 patients with BRCA1 positive expression, the remission rate was lower than the BRCA1 negative patients ( P <0.05 ) .80 cases of adverse reactions were seen as leukopenia, gastrointestinal symptoms (nausea and vomiting), abnormal liver function, BRCA1 expression of peripheral neurotoxicity, the incidence of complications in patients with positive expression were significantly higher than BRCA1 negative patients(P<0.05).N stage (P=0.03), BRCA1 gene (P=0.02) were independent risk factors of the prognosis of patients.Conclusion BRCA1 protein positive patients in lung cancer tissue had poor chemotherapy effect, more adverse reactions, and poor prognosis.
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<p><b>OBJECTIVE</b>To study the concentration change of chemotherapeutic agents in plasma and tissue after intraarterial and intravenous injection.</p><p><b>METHODS</b>Ten mature female New Zealand rabbits were divided randomly into two groups. Fluorouracil, etopiside, and cisplatin were injected into the rabbits through the ear vein in one group and through the internal iliac artery in the other group. Blood samples and the uterus tissue specimens were collected at various time points after injection. Drug concentration in plasma and tissue was determined by high performance liquid chromatography (HPLC) method. The data were analyzed by the pharmacokinetic program 3P97.</p><p><b>RESULTS</b>Regular concentration change of the three drugs in plasma and tissue was observed after the intravenous and intraarterial injection, which met the two - compartment model. The pharmacokinetic parameters of the three drugs after intravenous and intraarterial injection were different. The peak concentration in plasma after intraarterial injection was lower than that after intravenous injection and the peak concentration and area under curve (AUC) value in tissue after intraarterial injections were higher than those after intravenous injection.</p><p><b>CONCLUSION</b>Intraarterial chemotherapy has advantages to intravenous chemotherapy in fluorouracil, etopiside and cisplatin. These advantages depend on the drug pharmacological properties.</p>
Subject(s)
Animals , Female , Rabbits , Antineoplastic Agents , Blood , Pharmacokinetics , Cisplatin , Blood , Pharmacokinetics , Etoposide , Blood , Pharmacokinetics , Fluorouracil , Blood , Pharmacokinetics , Injections, Intra-Arterial , Injections, IntravenousABSTRACT
OBJECTIVE:To analyse the situation and characteristics of use of herbal decoctions,so as to find out the rules of drug-use in treatment of tumour METHODS:By means of the software named "Management System for Chinese Medicinal Herb Pharmacy in Tumour Hospital",usage of the herbal decoctions in treating tumours in this hospital from March 1997 to February 2000 was comprehensively analyzed RESULTS:There were six main categories,271 kinds of herbs used in this hospital which accounted for 58 15% of the total categories The amount of consumption reached 188 135kg which amounted to 83 03% of total consumption Among the top 20 kinds of herb in consumption,the tonics accounted for about 1/3,of which 61 45% for invigorating qi and 29 95% for nourishing yin and the herbs for clearing away heat and toxic material amounted to 65 30% of the total consumption of those for clearing away heat CONCLUSION:The Chinese traditional medicine is one of the most effective methods in preventing and treating tumours The average dosage of the herbs mainly used in treating tumour was about 30g,which is much larger than the common dosage
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Purpose:To study the relationship of chemosen sitivity in vitro and clinical experience.Methods:To analyze the results of chemosensitivity test in v itro using the MTT assay for 210 cases of five kinds of tumor specimens(85 ova rian cancer, 30 cervical cancer, 26 gastric cancer,41 colorectal cancer and 28 breast cancer), calculate the inhibitory average of each paclitaxel drug to diff erent tumor specimens,then compare the drugs haveing higher inhibitory average w ith the drugs frequently applied clinicaly to that tumor.Results:there is obvious individual variation in in vitro c hemosensitivity test, the variation can be from 0 to more than 60%;however the d rugs having higher inhibitory average correlated to clinical experience.The main theraputic drugs used clinically and also sensitive in in vitro assay were as follows:Taxol,DDP for ovarian cancer; DDP,e-ADM,MMC for cervical cancer ; DDP,5-FU,BLM,MMC for gastric cancer; DDP,MMC,BLM,5-FU for colorectal cancer; e-ADM,ADM,NVB for breast cancer.Conclusions:the chemosensitivity test using the MTT assay may b e useful for individual chemotherapy.
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Objective To study the incidence and treatment measures of complications in esophageal stenting.Methods The processes of implantation of esophageal stents in 60 cases were done,of them,59 cases were malignant disease and 1 case was benign stricture.All cases were followed-up for 3~24 months.The types of stents to be used including domestic metal-coated stainless steel Z-stent in 12 cases,domestic gridding-shape nickel-titanium memory alloy coated stent in 47 cases and imports stent in one.Results The processes were successful in all cases,the complications such as arrhythmia in 2 cases,suffocation in one case during operation,and chest discomfort and feeling of foreign body in 49 cases,nausea and vomiting in 15 cases,chronic infection of esophageal stent upper port in 2 cases,stent displacement in 6 cases,stent obstruction in 16 cases,massive hemorrhage,dyspnea and esophago-thoracic fistula in 1 case respectively for 1~36 weeks after operation.After clinical treatment,except 1 patient died due to bleeding shock,all complications were controlled or improved.Conclusion The majority of complications during or after treatment of esophageal stricture with stent implantation are slight,but the indications of operation should be strictly controlled.
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OBJECTIVE:To prepare cholecalciferol(VitD3)microcapsules and establish a method for their quantitative determination.METHODS:Microcapsules were prepared by complex coacervation method and VitD3 content was determined by HPLC.RESULTS:The prepared microcapsules had well-distributed particle size with average particle size of(103.9?26.2)?m and encapsulation efficiency of(90.8?2.68)%.The linear range of VitD3 was 0.1～1.0 ?g?mL-1(r=0.999 3)with mean recovery rate of 98.65% and a dissolution rate of above 75% at 45 min.CONCLUSION:VitD3 microcapsules was successfully prepared by the established method,and the established content determination method was proved to be simple and feasible.