two-year study of survival rate in children with Wilms tumor treated at Besat hospital of Hamadan [2005-2009]

Wilms tumor is one of the most common renal tumors in children. This type of tumor - accounting for 6 percent of tumors in children - shows a good prognosis if treated in time. This study is to investigate the clinical and pathologic findings as well as response to treatment in Iranian children with Wilms tumor treated at Besat hospital of Hamadan [2005-2009]. In this descriptive cross-sectional study all the 24 children - with confirmed diagnosis of Wilms tumor [by biopsy] treated at hematology ward [Hamadan Besat Hospital] from 2005 to 2009 - were followed up by monthly examination and 3-monthly Para-clinical evaluations after treatment. Patients were at 3 stages of the disease phase at the time of diagnosis. Two patients had unfavorable histology. The most common clinical finding was abdominal mass. 2-year survival of the patients in stages 1 and 2, and stages 3 and 4 was 100% and 83%, respectively. Out of the total number of the patients, 4 cases referred with the recurrence of the tumor [16.7%]. Two of them were expired. The findings of the present study showed that the survival rate observed in this study was better than other studies in this field

[Gallblader sonographic abnormality following ceftriaxone treatment in children]

Considering the relatively wide application of ceftriaxone in pediatric infectious diseases and its side effects, this study was done to determine gallblader sonographic abnormality following ceftriaxone treatment in children. This descriptive cross-sectional study was carried out on 60 patients age 1 month up to 12 years in Besat hospital, Hamadan, Iran during 2007. The sonographic abnormal finding of gallbladder before ceftriaxone therapy and 5 days after therapy were recorded. In case of any abnormality in gallblader sonography was repeated twice a week in the first two weeks and afterward once a week up to disappearance of abnormalities. Gallblader sonographic abnormality were observed in 10 cases [16.5%]. Out of them, 8 and 2 patients had bile stone and bile sludge, respectivley. The patients did not show any clinical manifestations. There was no relation between age and sex with abnormal findings. Gallblader abnormality completely were disappeared in the worst cases by sixteen days. This study showed that the incidence of either gallstone or biliary sludge after treatment with ceftriaxone was 16.5% which is relatively similar to other studies

Comparing antioxidant capacity and vitamin C values between umbilical cord and maternal blood plasma and those in newborns with hypoxia

Oxygen intoxication plays an important role in the pathogenesis of some fetal diseases such as encephalopathy, ischemia and hypoxia. Antioxidants can reduce oxidative damage in newborns. The object of this research was measuring total value of antioxidant and vitamin C in blood sample of pregnant women before delivery, and also in umbilical cord blood of their newborn, and repeating these measurements 48 hours after birth in newborns with hypoxia and controlling group. The sample included 32 healthy pregnant women presented for delivery and also their newborns. The total values of antioxidant and vitamin C in plasma were measured by staining methods. There was no statistical meaningful difference in total values of antioxidants and vitamin C in women's blood and their newborn's cord blood. Also total values of antioxidant and vitamin C meaningfully increased in newborns with hypoxia after 48 hours. total values of antioxidant and vitamin C in blood plasma of newborn, increases in oxidative damage as a defense mechanism

[Survey of clinical and para-clinical findings in children with acute appendicitis]

Background: The acute appendicitis is the most common surgical intervention and urgency during the pediatric age group. The most important challenge is the problem of diagnosis. The aim of this study is survey of clinical presentation, laboratory data in acute appendicitis confirmed by pathology and comparing with those who had normal pathology

Methods: This is a cross-sectional description study on 140 children less than 16 years of age who had appendectomy at Shahid-Mobasher Kashani and Ekbatan Hospitals in Hamedan. All clinical and paraclinical data were collected by checklists and analyzed statistically by SPSS

Results: 105 patients [75%] had pathologic findings and 35 patients [25%] had normal appendices. There were statistically significant association [P<0.05] between the frequency of appendicitis with sex, vomiting, RLQ pain, leukocytosis and shifting to left in peripheral blood smear

Conclusion: Because of high rate of appendectomy with negative pathologic finding, in suspected cases, the proper history, frequent clinical examination, close observation, and other modalities as graded compression sonography. CT scan and laparoscopy should be considered