ABSTRACT
This study was conducted to investigate the possible involvement of the histaminergic system in the mediation of ghrelin-induced feeding behavior in broilder chickens. In the trial 1, the effect of intracerebroventricular [ICV] injection of ghrelin on feed intake was examined in 3-h feed-deprived broiler chickens. In the trials 2 and 3, the chickens were received ICV chlorpheniramine [an H[1] receptor antagonist] was measured at 2-h post injections. Infusion of ghrelin [0.3, 0.6 and 1.2 nmol] decreased feed intake dose-dependently [P<0.05]. Pre-treatment of chlorpheniramine [100 micro g] attenuated the inhibitory effect of ghrelin results suggest that there is an interaction between ghrelin and the histaminergic system [through H[1] receptors] on control of feed intake in broiler chickens