ABSTRACT
The calculi must be analyzed to find urolithiasis etiology. This investigation will allow adopting the appropriate action to avoid the stone's recurrence. Infrared spectroscopy, the reference method in calculi analysis, is unfortunately very expensive that we can't use it in our laboratory. In this study, we determine the molecular composition of urinary calculi from children using a simple and inexpensive protocol. We used the chemical method in association with optical method using binocular lens to make it more effective. We applied this protocol in studying urinary calculi collected from forty seven children and we analyzed the results according to clinical and radiological data. Our patients were aged between 2 and 16 years. The majority of them [81%] were aged over 4 years. The vesical calcui represented 51%. The calcium oxalate calculi were dominant [61,7% of cases]. The principal majority component varied according to children's age. At age less than five the major component was calcium phosphate which represented 44% while calcium oxalate represented only 22%. However, at the age of five and over, these kinds of components represented respectively 13,5% and 71% of cases. Struvite, cystin and uric acid were predominant in 6,38% of cases. This protocol allowed us to determine the molecular composition of all studied stones. It had permitted also to identify their etiology in one third of cases and to orient it in the remaining cases
Subject(s)
Humans , Male , Female , Child , Molecular StructureABSTRACT
Through the observation of seven cases we reported the epidemiological, clinical, paraclinical, evolutionary and therapeutical aspects of this disease. Epidemiologically, the sex ratio is of 0,75. The medium age is of six years and two months. Factors in favor of a hereditary origin are the consanguinity found in 28,6% of cases and the presence of a similar case in the family observed in 42,3%. Clinically, the quasi constantly neurolgical signs are ataxia [100%], dysarthria [71, 4%], areflexia of endon reflex in both lowner limbs [57,14], deep sensation troubles are less frequent [28,6%]. Vestibular affection with form of horizontal nystagmus is found in 14,3% of cases. The dysmorphic syndrome is in the form of claw feet found in [57,14%] and of dorsal scoliosis in [14,3%]. Cardiac affection in the form of cardiopathy is noted in two magnetic resonance imagery in one patient. The electromyography is disturbed in 28.6% of cases. The genetic study done to two cases [28,6%]. Paraclinically, we found cerebellar atrophy in 57,14% which was confirmed by cases showed an expansion of the triplet GAA at the level of the chromosome nine. Improvement under symptomatic treatment based on muscular and functional physiotherapy was progressively slow for all our patients