Formulation and evaluation of mastic in antacid preparations

Mastic, as a herbal material having antiulcer activity, was investigated as a binder for tablets containing the antacid; namely, calcium carbonate or magnesium trisilicate. The tablets were evaluated with regard to physical st and ards and antacid efficacy. The data were compared with those obtained from tablets containing the traditionally used binders and some commercial antacid tablets. The results revealed that the use of mastic at high concentrations [15 and 20%] produced tablets with good mechanical properties [6-9.4 kg] and with a short disintegration time [up to 4 minutes] that satisfied the FDA requirements for this kind of tablets. In addition, the antacid efficacy of magnesium trisilicate was very slightly affected, while the antacid efficacy of calcium carbonate was markedly reduced. Both pHs of simulated gastric fluids were suitable for the digestive enzymes activity in the stomach after the addition of mastic-containing antacid tablets

Physical and dissolution characteristics of ibuprofen and diclofenac sodium tablets made with polyacrylamide

Tablets containing polyacrylamide were investigated with regard to their physical st and ards and release profile. The use of this polymer gave tablets of good mechanical property especially with Avicel regardless of both type of the medicament and concentration of the polymer. The tablets disintegrated very rapidly only at low concentrations of the polymer. In addition, a sustained release behavior was obtained depending upon the solubility of the drug and type of diluent. The tablets containing Avicel released about 47% and 59% diclofenac sodium and ibuprofen, after about 6 hours employing 20% polymer concentration. On the other h and, at least 30% polymer concentration was required to produce such effect for tablets containing spray dried lactose. Generally, most of tablets showed a typical square root of time release according to Higuchi equation

Evaluation and tableting characterization of spironolactone-B-cyclodextrin complex prepared by double compression technique

In this study, double compression technique [slugging] was evaluated to prepare SP-BCD complex. The prepared complex was evaluated by infrared [IR] and X-ray diffraction and compared with solid state complexes prepared from aqueous solution and partitioning technique. The SP-BCD powders were formulated into tablets and evaluated for their physicochemical properties. The aqueous solubility of SP from the prepared complexes and physical mixtures was found to be similar. The IR and X-ray diffraction studies of SP-BCD slugs indicated the presence of a mixture of amorphous, crystalline and inclusion complex. The tablet properties showed variations in hardness and disintegration time values. The dissolution rate of SP from tablets containing slugs was similar to those containing the other SP-BC complexes, while tablets prepared without BCD showed a very slow dissolution rate

Release pattern of dyphylline tablets containing polyion complexes made from chitosan with anionic polymers

With a view to the application of chitosan [CS] for drug delivery, interpolymer complexes of CS with each of carbopol 934 [CP] and carboxymethyl cellulose [CMC] were investigated employing viscosity measurement. The stoichiometry of binding were 1:4 and 1:2 for CS:CMC and CS:CP complexes, respectively. Physical mixtures 50% of each CS:CMC and CS:CP in different ratios including those of their complexes were directly compressed to tablets containing 50% w/w of dyphylline as a model drug. In acid medium, the most precise sustained behavior from CS:CMC and CS:CP matrices were found at ratios of 1:4 and 2:1, respectively, indicating the formation of the complex during dissolution. In phosphate buffer, however, CS disintegrated and released from the physical mixture was dependent on the weight fraction of either CMC or CP. The drug release pattern from increased pH milieu was almost similar to that in acid medium. Even low percentage of matrix [CS:CP and 10% concentration], also showed sustained release effect