Clinical significance of esophageal groove-vasopressin induced-closure: 1-A new concept in the treatment of non specific diarrhoea in adult buffaloes

The effect of lysine-vasopressin on oesophageal groove closure was studied in adult buffaloes. Sixteen animals were allocated to 4 groups. Each group was tested for the effect of the dose rate 0.01, 0.03, 0.2 or 0.5 I.U/Kg IBW respectively. Both efficiency and period of closure were determined by indirect methods. Efficient and prolonged closure was achieved by the dose 0.5 I.U/Kg, a reliable effect by 0.2 I.U/Kg, while 0.03 was the least effective. Furthermore, 23 adult buffaloes suffered from non specific diarrhoea, were treated symptomatically with ADD-charcoal mixture given as a drench once daily for 3 successive days. Eight animals received the mixture alone, 10 animals received the mixture after premedication with lysine-vasopressin at the dose rate of 0.2 I.U/Kg IBW. The other animals remained without treatment as control. Animals premedicated with lysine-vasopressin showed rapid and high recovery with clinical improvement in feacal character, bodily condition, P.C.V.% and total proteins. The other animals showed no perceivable improvement

Clinical significance of oesophageal groove vasopressin induced-closure 2-A new concept in the oral glucose treatment of pregnancy toxanemia in ewes

Treatment of pregnancy toxaemia was carried out in two groups of diseased ewes, four animals each. The first group [Ga] was treated with the standard replacement therapy; I.V. glucose followed by oral glycerol as a glucogenic substance. The second group [Gb] was treated with oral glucose after pre-medication with lysine vasopressin [LVP] to induce oesophageal groove closure. Both treatments were given twice a day for three successive days. Response of treatments and recovery were monitored daily through clinical and biochemical examinations. Twenty four hours after the last treatment ewes of the first group [Ga] showed neither clinical nor significant biochemical improvement, but lambing or induction of abortion was the crucial factor. On the other hand 3 out of 4 ewes of the second group [Gb] showed an improved appetite twenty four hours after the first treatment, and complete recovery was achieved before lambing. Recovery was accompanied with significant [p>0.01] increase of plasma glucose and decrease of plasma NEFA and total ketone bodies

Urea-ammonia toxicity: 2- Some hematological and biochemical investigations on lactulose concentrate treatment

Urea-ammonia toxicities were induced in 3 groups of rumen fistulated sheep. The toxic signs were associated with the pathologically elevated blood ammonia N. The stress of toxicity provokes a significant [P>0.01] increase of P.C.V. percent, haemoglobin contents and blood glucose level. Also there was a significant [P>0.01] increase of the S-AST and S-ALT activities. Both rumen evacuation and lactulose concentrate administration, but not acetic acid treatment, resulted in a decline of the pathologically elevated blood ammonia-N with subsequent improvement of the intoxicated animals. The changed blood constituents returned to more or less normal values and the animals expected to be clinically recovered