role of Zizyphus spina christi extract and bifidobacterium as a biotherapeutic agent in prevention of osteoporotic postmenopausal women

The objective of this study was to evaluate the efficacy of the consumption of bioactive yogurt [probiotic] in combination with Nabq fruit [Zizyphus Spina Christi, ZSC] extract as bioavailable isoflavone in osteoporotic postmenopausal women..Analysis by HPLC of ZSC extract showed that the main constituents of this extract exhibited a chromatographic profile corresponding to rutin, quercereterin, quercin, kamaferol, chlorogenic and ferrulic. The study was conducted on 25 postmenopausal women.Our results revealed that the level of serum osteocalcin [OC] was significantly decreased on daily consumption of yogurt fortified with Bifidobacteria in combination with ZSC extract. This indicated down-regulation of bone turn-over. The level of serum parathyroid hormone [PTH] and ionized calcium [Ca2+] were also reduced significantly. This study proposed that phytoestrogens efficacy of ZSC extract in combination with probiotics prevent bone mineral loss due to ovarian estrogen deficiency possibly by promoting intestinal calcium absorption and enhancing antiresorptive agent in osteoporotic postmenopausal women

Impaired vitamin B-12 and folate absorption as a risk factor for hyperhomocysteinemia in ileal neobladder

The terminal ileum is widely used for reconstruction of the lower urinary tract since the terminal ileum exclusively absorbs vitamin B-12, removal of ileum from the gastrointestinal tract for lower urinary tract reconstruction may predispose patients to vitamin B-12 deficiency. The purpose of this study is to evaluate the long term metabolic and nutritional effects of incorporating intestinal segments in urinary tract on the levels of vitamin B-12 and/or folic acid and their relation with the level of total homocysteine in patients suffering from bladder cancer. This study included twenty seven patients suffering from bladder cancer, with mean age 45 +/- 8.34 years. Twenty one healthy subjects were included in this study to serve as control. The levels of serum vitamin B-12, folic acid and total homocysteine [T-Hcy,] were estimated. Serum T-Hcy level was significantly elevated in pre- and Postoperative patients suffering from bladder cancer when compared to control. The levels of serum vitamin B-12 and folic acid were significantly reduced the drop was markedly increase during 5 months to two years. In conclusion, patients with terminal ileal neobladder reconstruction [5 months - 2 years] of the urinary tract had deficiency of vitamin B-12 and folic acid. Also those patients had hyperhomocysteinemia due to this deficiency. Life long surveillance of vitamin B-12 level annually, that a modest supplement be sampled before twice yearly [by injection may be beneficial and that serum vitamin B-12 must he giving vitamin B-12 injection to avoid cardiovascular disease complication