Mediterranean glucose-6-phosphate dehydrogenase [G6PD[c563t]] mutation among jordanian females with acute hemolytic crisis

To evaluate the G6PD[c563t] Mediterranean mutation among Jordanian females who were admitted to Princess Rahma Teaching Hospital [PRTH] with/or previous history of favism. A descriptive study. Jordanian University of Science and Technology and PRTH, from October 2003 to October 2004. After obtaining approval from the Ethics Committee of Jordanian University of Science and Technology, a total of 32 females were included in this study. Samples from 15 healthy individual females were used as a negative control. Blood samples from these patients were collected and analyzed by allele-specific polymerase chain reaction [AS-PCR] to determine the GGPDcsesr mutation. Twenty one out of 32 patients were found to be G6PD[C563t] Mediterranean mutation [65.6%] positive. Three out of 21 patients were homozygous and remaining 18 were heterozygous for G6PD[C563t] Mediterranean mutation. Eleven [34.4%] out of 32 patients were found to be negative for G6PD[C563t] mutation indicating the presence of other G6PD mutations in the study sample. G6PDC563T Mediterranean mutation accounted for 65.6% of the study sample with favism in the North of Jordan. There is likely to be another G6PD deficiency variant implicated in acute hemolytic crisis [favism]

Transverse lie in Northern Jordan: risk factors, obstetric and perinatal outcome

This study describes the incidence, risk factors, obstetric and perinatal outcome of transverse lie in singleton pregnancies at term at the Princess Badeea Teaching Hospital in Northern Jordan. A retrospective study was undertaken for woman who delivered over a 5-year period from January 1997 to January 2002. There were 164 cases of term transverse lie out of 45,763 deliveries during the study period. The incidence of transverse lie at term was 0.36%. This occurred more commonly in grandmultiparous[79.3%] in comparison to low parous [14.6%] and primigravid [6.1%] woman. The most common risk factors associated with transverse lie were placenta praevia [7.3%], polyhydramnios [4.9%], uterine anomalies [3.7%] and contracted pelvis [3%]. The antenatal and intrapartum complications associated with this condition were premature rupture of membranes [10.4%], antepartum haemorrhage [6.1%] cord prolapse [3%] and uterine rupture [0.6%]. The majority of women were delivered by emergency caesarean section [73.8%] and 18.9% of women were delivered by elective caesarean section. External cephalic version and successful vaginal delivery were achieved in 7.3% of women. The perinatal mortality was 42.7 per 1000 births. There were 7 cases of perinatal deaths; 3 stillbirths and 4 early neonatal deaths. Better antenatal care and the use of ultrasonography will lead to early diagnosis of transverse lie. Elective admission and delivery, whether by caesarean section of vaginally after external cephalic version of such cases will minimize if not completely eliminate, the major, hazards associated with transverse lie in labour