ABSTRACT
Background: the skin displays the most visible manifestations of aging. Research interest in aging process has grown and people are becoming obsessed with looking young. The face has received most of the attention and generated most of the studies related to beauty and aging because it is the most expressive part of human body
Aim of the Work: to assess the different clinical patterns of facial wrinkles and signs of skin aging among different age categories of Egyptian females
Subjects and Methods: this cross-sectional study was carried out in the Dermatology, Venereology and Andrology department of Ain Shams University Hospitals after Institutional Review Board approval. The study included included 100 adult females ranged from 20-60 years old
Results: the mean age was [38.570 +/- 11.634] with a range of 20-60 years. Skin phototype was Fitzpatrick Type III in 8 patients [8%], IV in 55 females [55%] and V in 37 females [37%]. Glogau classification for severity of skin aging signs was type I in 39 cases [39%], Type II in 20 [20%], Type III in 26 [26%] and type VI in 15 [15%]. All patients reported history of excessive sun exposure for extended hours; 32 cases reported sunscreen use but not regular, while 68 cases didn't use sunscreen
Conclusion: skin Type IV showed more wrinkles indentation index, roughness, melanin concentration, melanin heterogeneity and HGB heterogeneity. There was a significant correlation between the sunscreen use and average melanin concentration, where cases that used sunscreen showed lower average melanin concentration. The relation between sun screen use and severity of wrinkles [Indentation index] was non-significant
ABSTRACT
Psoriasis is a common, chronic inflammatory skin disease with unknown etiology. It has been suggested that increased reactive oxygen species [ROS] production and deficient function of antioxidant systems activities may be involved in the pathogenesis of the disease. The goal of this study was to determine the role of lipid peroxidation, assess the antioxidant activity in psoriasis patients and to correlate it with severity of the disease. In this study malondialdehyde [MDA], super oxide dismutase [SOD] enzyme activity, and total antioxidant oxidative capacity [AOC%], Vit E and beta carotene levels in 24 patients with psoriasis were investigated and compared with those of 12 control subjects. Clinical severity of the disease was determined according to the Psoriasis Area Severity Index [PASI] scores in patients. Our results showed that MDA as a marker of oxidative stress was significantly higher in psoriatic patients, while AOC%, SOD, Vit E and beta carotene as markers of antioxidant status were significantly lower in psoriatic patients compared to control. However, there was no correlation between PASI score and plasma AOC% and erythrocyte SOD levels. In conclusion our results may provide some evidence for the role of ROS production associated with decrease antioxidant potential in psoriasis