ABSTRACT
Objective: To investigate the changes of white matter in patients of end-stage renal disease (ESRD) with secondary hyperparathyroidism (SHPT) by using local diffusion homogeneity (LDH). Methods: Fifty patients diagnosed as ESRD and underwent hemodialysis were selected. According to whether with SHPT or not, the patients were divided into SHPT group and non-SHPT group (each n=25). The cognitive function was evaluated with Montreal cognitive assessment (MoCA). Then MR plain scan was performed. The LDH value of white matter fiber in the whole brain were compared between 2 groups based on voxel. Results: Compared with non-SHPT group, SHPT group showed diffuse and symmetrical LDH decreased area in bilateral cerebral hemispheres, and in the focal right cerebellar hemispheres (all P0.05). Conclusion: LDH value can provide information of the white matter's LDH in ESRD patients with SHPT, and the changes are related to cognition and clinical indicators.