ABSTRACT
OBJECTIVE: To review the literature on beta-cell neogenesis and regeneration, with special interest in substances that regulate such processes. DESIGN: Representative papers were selected through a computer MEDLINE search from 1990 to 2000. RESULTS: Several studies showed that once islets of Langerhans developed from small pancreatic ducts, this process did not continue in normal adult individuals. However, it has been published that new beta-cell formation can occur in vivo in certain experimental models through neogenesis, in which gene pax 4 is extremely important. On the other hand, substances that stimulate the regenerative process of beta-cells include glucose, several hormones and certain growth factors. CONCLUSIONS: Substances that stimulate the regenerative process commonly express this effect in elevated, non-physiologic concentrations; thus, their possible therapeutic importance is not yet clear. Nevertheless, the Reg protein, present in regenerative pancreas and implied in neogenesis process, has actual possibilities of becoming therapeutically important.