Detection of interleukin 8 and auto antibodies to interleukin 8 in the serum of patients with lichen planus

An enzyme linked immunosorbant assay ELISA was used to determine the serum concentration of interleukin 8 and auto antibodies to interleukin 8 in fifteen patients with oral lichen planus only, seven patients with oral and skin lichen planus as well as ten healthy control subjects. Interleukin 8 was detectable in the serum of eleven of fifteen patients with lichen planus and five of seven patients with oral and skin lichen planus but none of the healthy controls showed detectable serum interleukin 8. Significantly, elevated auto antibodies to interleukin 8 were detected in two patients groups. However, their values did not correlate significantly with clinical condition of the disease including affected side; distribution and the duration. The results of this work may [lend] support the role of immune mechanism in the etiopathogenesis of oral lichen planus

Therapeutic effect of tinidazole in periodontal disease I- clinical evaluation

Twenty-four patients participated in the study. Every patient received scaling and root planing for one side and the other side was left without scaling to serve as control. All patients were given 1 g of tinidazole for 2 days. The gingival index, plaque index, periodontal index and the periodontal pocket depth were recorded before scaling and at 2, 6, 8 weeks. There was an improvement in the periodontal health status, which may suggest the use of tinidazole as valuable adjunct in the periodontal therapy