Pharmacokinetics of oral ranitidine in Mexicans

The pharmacokinetics of oral ranitidine were studied in 24 Mexican male healthy volunteers. Subjects received a tablet containing 150 mg of ranitidine (Azantac TM, Glaxo de Mexico, Mexico, City) after an overnight fast and blood samples were drawn at several times for a period of 24 h. Ranitidine concentration in plasma was measured by high performance liquid chromatography and pharmacokinetic parameters were determined by non-compartmental analysis. Ranitide plasma concentration increased with time, reaching a maximum of (mean ñ SEM) 484 ñ 34 ng/ml in 2.7 ñ 0.2 h. Plasma levels then decayed with a terminal half-life of 4.8 ñ 0.3 h. The area under the plasma concentration against time curve was 2440 ñ 126 ngh/ml. Oral ranitidine pharmacokinetic parameters in mexicans appeared to be similar to those previously reported for caucasians

Efectos del aguacate sobre los niveles de lípidos séricos en pacientes con dislipidemias fenotipo II y IV / Effects of avocado plasma lipid concentrations in patients with hypercholesterolemia

Para examinar el efecto del aguacate sobre los niveles de lípidos séricos en pacientes dislipidémicos, se incluyeron a 8 sujetos con dislipidemia fenotipo IV y 8 del fenotipo II en un estudio dietético, en un modelo cruzado en el que se compararon dos dietas: una dieta rica en ácidos grasos monoinsaturados (DRCA), en la que el aguacate fue su principal fuente (30 por ciento de calorías totales como grasas y de ellas 75 por ciento del aguacate), con restricción de grasas saturadas y menos de 300 mg de colesterol por día. La otra fue una dieta baja en grasas saturadas y en grasa total, sin aguacate (DRSA). Ambas dietas duraron 4 semanas y su orden fue asignado aleatoriamente. Los pacientes realizaron sus tres alimentos en el comedor de nuestra unidad. Tanto la DRCA como la DRSA redujeron significativamente los niveles de colesterol total y colesterol-LDL sólo en el fenotipo II. En el fenotipo IV, la DRCA produjo un descenso moderado de los triglicéridos, mientras que la DRSA incrementó sus niveles. La DRCA produjo un importante incremento en los niveles de colesterol-HDL en ambos fenotipos, mientras que la DRSA sólo lo hizo en el fenotipo II. El aguacate es una excelente fuente de ácidos grasos monoinsaturados, y puede utilizarse dentro de los planes dietéticos de manejo de los pacientes con dislipidemias, con ventajas sobre las dietas más bajas en grasa total y con mayor cantidad de carbohidratos

Determination of oral rifampin pharmacokinetic parameters in Mexicans and comparison with other populations: absence of evidence for interethnic variability

Oral pharmacokinetics of rifampin were studied in eight Mexican young healthy male volunteers after administration of a 600 mg oral dose. After and overnight fast, subjects received medication and blood samples were drawn at selected time over a 24-h period. Rifampin plasma levels were determined by HPLC. Pharmacokinetic parameters (mean ñ SEM) were: Cmax 13.514 ñ 1.775 µg/ml, tmax 1.88 ñ 0.30 h, AUC 73.61 ñ 9.48 µg.h/ml anf half-life 2.98 ñ 0.29 h. Results were compared with those obtained for the other populations under similar conditions in order to explore the possibility of interethnic variability, since it has been reported that rifampin pharmacokinetics in Indonesian subjects differ from those found in Europeans. Pharmacokinetic data found in Mexican were comparable with those observed in Brithis, Indian, Japanese and Italian individuals. As the parmacokinetics of rifampin seem to be similar different populations, it is concluded that ethnic origin does not a appear to play and important role. Therefore, dosing regimens designed for Caucasians can be extrapolated for other populations