Study on application of spreading cellules to investigate on skin absorption possibility of drug from TTS - nitroglycerin

The researchers built targets and way to handle skin and built quantitative method notroglucerin by high-performance liquid chromatography (HPLC) and quantitative method total nitroglucerin content in sticking-plaster Discotrin 36mg with area of 13,3cm2. The study was carried out in 6 samples and average with RSD = 0,47%, from there find out exactly nitroglycerin level on 1cm2 to evaluate permeation of nitroglycerin through skin in different temperatures ( 41oC, 37oC, 25oC). The result showed that the higher temperature, the more Nitroglycerin is permeated. The permeation of nitroglycerin through skin is defferent in each animal

Arrhymias in hypertensive left ventricular hypertrophy (LVH) patients by 24-hour Holter ECG

The study on 24-hour ambulatory eclectrocardiographic monitoring for 74 hypertensive patients (34 had LVH) without coronary heart disease, diabetes and 34 normal people, the groups were matched for age, sex, BMI, risk factors. Results: the frequency of supraventricular, ventricular arrhythmias and complex ventricular arrhythmias (Lown grade 3-5) in hypertensive patients, especially hypertensive left ventricular hypertrophy patients, were significantly higher than in control group. Arrhymias in hypertensive patients were associated with age, LVM. The hypertension increased the risk of supraventricular arrhythmias by 7.2 folds, ventricular arrhythmias by 7.4 folds. The hypertension with LVH increased the risk of ventricular arrhythmias by 4.04 folds, especially increased the risk of complex ventricular arrhythmias to 7.6 folds in comparison with hypertension without LVH

Study on modernisation of traditional medecine prescriptions with the aid of extraction industry and chemie of natural compounds

The study for modernization of traditional prescriptions with the help of new technology of extration and chemistry of natural compounds. With the help of new technologies, 3 traditional prescriptions – Luc Vi, Dai Bo Am, Cam Cum were modernizied. The newly prepraed product – tablets, capsules coated tablet had got pharmacopia criteria and had assured the therapentic effects, the safety thestability, the quality and the utility as the heritage of traditional medicines

To review 250 cases of large corneal transplantation in 1985-1997 year period

From the year 1985 – 1997, 250 cases of corneal transplatation were reviewed. The diameter of grafted cornea varied from 8-15mm, among them 113 cases of graft larger than 10mm. After the operation, visual acuty was improved in almost patients. In the case of internal therapy is impossible, this surgery is the only approach to save the eyeball, moreover, the optical function was restored significantly. In the case of progressive infection, which is not responded to the therapy, threatening the eyeball corneal transplantation must be indicated early.

Preliminary study on manufacture process of transdermal patch of nitroglycerin

Nitroglycerin, a vasoactive substance, has been used in the treatment of vagina for more than 100 years. To sustain the pharmaceutical effect, doses were administered every 2 hours. Recently the transdermal delivery systems have became popular. Based on eudragit E 100, we combined it with plasticizer (dibutyl sebacate/triethyl citrate), crosslinker (succinic acid), active ingredient (nitroglycerin) and further excipients (e.g. permation enhances: ethyl alcohol) to form a self adhesive matrix system for use in nitroglycerin patch. The concentration of nitroglycerin in the patch was determined by HPLC assay