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OBJECTIVE@#This study investigated trends in the study of phytochemical treatment of post-traumatic stress disorder (PTSD).@*METHODS@#The Web of Science database (2007-2022) was searched using the search terms "phytochemicals" and "PTSD," and relevant literature was compiled. Network clustering co-occurrence analysis and qualitative narrative review were conducted.@*RESULTS@#Three hundred and one articles were included in the analysis of published research, which has surged since 2015 with nearly half of all relevant articles coming from North America. The category is dominated by neuroscience and neurology, with two journals, Addictive Behaviors and Drug and Alcohol Dependence, publishing the greatest number of papers on these topics. Most studies focused on psychedelic intervention for PTSD. Three timelines show an "ebb and flow" phenomenon between "substance use/marijuana abuse" and "psychedelic medicine/medicinal cannabis." Other phytochemicals account for a small proportion of the research and focus on topics like neurosteroid turnover, serotonin levels, and brain-derived neurotrophic factor expression.@*CONCLUSION@#Research on phytochemicals and PTSD is unevenly distributed across countries/regions, disciplines, and journals. Since 2015, the research paradigm shifted to constitute the mainstream of psychedelic research thus far, leading to the exploration of botanical active ingredients and molecular mechanisms. Other studies focus on anti-oxidative stress and anti-inflammation. Please cite this article as: Gao B, Qu YC, Cai MY, Zhang YY, Lu HT, Li HX, Tang YX, Shen H. Phytochemical interventions for post-traumatic stress disorder: A cluster co-occurrence network analysis using CiteSpace. J Integr Med. 2023; 21(4):385-396.
Subject(s)
Humans , Stress Disorders, Post-Traumatic/drug therapy , Hallucinogens/therapeutic use , Substance-Related Disorders/drug therapyABSTRACT
Objective :To explore influencing factors of severity and aggravation of coronary heart disease (CHD ). Methods : A total of 132 CHD patients ,who were treated in our department from Mar 2015 to Mar 2017 ,were en-rolled .According to Gensini score ,patients were divided into mild disease group (n＝64) ,moderateand severe dis-ease group (n＝68).Relevant clinical data were collected ,and single-factor and multi －factor regression were used to analyze risk factors of coronary artery disease aggravation .Results :Clinical data indicated that diabetes mellitus (DM) ,smoking ,age ,body mass index (BMI) and blood lipids were influencing factors for coronary artery disease severity ( P＜0-05 or ＜0-01).Single factor regression analysis indicated that age ,smoking history ,DM history and dyslipidemia were influencing factors for coronary artery disease aggravation , P＜0-05 or ＜0-01 .Logistic multi－factor regression analysis indicated that dyslipidemia and smoking history were independent risk factors of aggrava-tion of coronary artery disease .(OR＝3-249 ,7-135 , P＝0-008 ,0-001).Conclusion : Severity of coronary artery disease is closely related with DM ,smoking history and dyslipidemia in CHD patients .And dyslipidemia and smok-ing history are independent risk factors for coronary artery disease aggravation .
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Hydrogen is colorless and odorless small molecule gas with biological activity, and it can react with reactive oxygen species. It is believed that hydrogen has biological effects such as anti-oxidation, anti-inflammation and anti-apoptosis, and has extremely high biosafety. Recently, hydrogen application has been involved in various acute and chronic diseases, and benign and malignant diseases. In addition, means of hydrogen utilization is also enriched, including hydrogen inhalation, hydrogen-rich water drinking, intravenous injection or partial use of hydrogen-rich saline and dialysis of hydrogen-rich dialysate. More importantly, the increasing hydrogen-related clinical studies have further demonstrated that hydrogen is effective and safe for diseases. However, the molecular mechanism of hydrogen biological effects is not very clear, and many scholars and the general public lack an understanding of hydrogen development status, which limits the development of hydrogen medicine and the related products. The research and popularization of hydrogen medicine is still a work in progress.
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OBJECTIVE@#To investigate the polymorphism of the TPH gene T3792A locus in Han ethnic group of north China and its application value in forensic science.@*METHODS@#The polymorphism of T3792A locus of the TPH gene was analyzed by the ASPCR of blood samples from 173 unrelated individuals of north Chinese Han population.@*RESULTS@#The distribution of the T3792A locus polymorphism of the TPH gene in Han ethnic group of north China followed the Hardy-Weinberg law, with the allele A and T gene frequency of 0.486 and 0.514, respectively.@*CONCLUSION@#The TPH gene T3792A locus shows a very good genetic polymorphism, and may be applied to individual identification and paternity testing.
Subject(s)
Humans , Asian People/genetics , China/ethnology , Forensic Genetics , Gene Frequency , Paternity , Polymorphism, Genetic , Tryptophan Hydroxylase/geneticsABSTRACT
OBJECTIVE@#To study the distribution of the tryptophan hydroxylase (TPH) gene-T457C locus polymorphism in Han ethnic group in northern China and to find its applicable value in forensic science.@*METHODS@#Genomic DNA samples, extracted from 180 unrelated individuals in northern Chinese Han population, were analyzed by PCR-RFLP.@*RESULTS@#The discrimination power (DP) value and the power of exclusion (PE) value of the TPH gene-T457C locus were 0.624 and 0.187, respectively. The allele frequency showed significant difference from that of French people (P=0.04).@*CONCLUSION@#Polymorphism of the TPH gene-T457C locus could show ethnic and regional differences. It has a potential to be used in forensic science.