Death Trend of Lung Cancer in China from 2006 to 2020 Based on Age-Period-Cohort Model / 肿瘤防治研究

Objective To analyze the trend of lung cancer death rate in China from 2006 to 2020 to provide reference for the prevention of lung cancer. Methods The data of Chinese lung cancer deaths from 2006 to 2020 were collected from the health statistical yearbook.The age-period-cohort model and intrinsic estimator algorithm were used to evaluate the age, period, and birth cohort effect of lung cancer deaths. Results The overall lung cancer mortality of Chinese residents showed an upward trend from 2006 to 2020.The age effect of lung cancer death risk increased with age, and the period effect continued to increase with age.The cohort effect showed that the lung cancer death risk of residents born after 1924 showed a downward trend. Conclusion The prevention and treatment of lung cancer in urban and rural residents aged 50 and above and the treatment of high-risk factors of lung cancer must be continuously strengthened.The period effect on lung cancer should be further explored, and the early intervention of young cohort should be given attention.

Effects of resistance training on weight in college students / Efeitos do treinamento de resistência sobre o peso em universitários / Efectos del entrenamiento de resistencia sobre el peso en estudiantes universitarios

ABSTRACT Introduction: Obesity has a great negative impact on college students, affecting their physical and mental health. It is believed that resistance training, as an aerobic exercise that promotes muscle hypertrophy, can promote an obesity-reducing effect in this class of individuals. Objective: Assess the effects of resistance training with loads on weight in college students. Methods: 120 obese college student volunteers were equally and randomly divided into groups for the experiment. The experimental groups A and B received resistance training with different loads, while the control group received only regular aerobic training. For statistical analysis and discussion, body indices such as perimetry and BMI were collected before and after the intervention. Results: After the experiment, the body weight of experimental group A changed from 81.62±4.12 to 76.20±5.49, BMI from 27.22±1.67 to 25.98±1.74, waist circumference from 89.11±5.62 to 87, 27±6.34, hip circumference from 101.61±5.43 to 98.45±5.62, waist/hip ratio from 0.89±2.34 to 0.87±2.13, and body fat ratio from 27.58±3.83 to 22.61±2.99. Significant changes were also noticed in the data of experimental group A after resistance training with different loads. These changes were similar to those of the experimental group B, but changes in the control group data were not evidenced. Conclusion: Resistance training with loads can help obese college students improve their body composition and physical quality. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMO Introdução: A obesidade tem um grande impacto negativo sobre os estudantes universitários, tanto sobre a saúde física, quanto também na saúde mental. Acredita-se que o treinamento de resistência, como um exercício aeróbico promotor de hipertrofia muscular, possa promover um efeito redutor da obesidade nessa classe de indivíduos. Objetivo: Verificar os efeitos do treinamento de resistência com cargas sobre o peso em estudantes universitários. Métodos: 120 estudantes universitários obesos voluntários foram divididos igual e aleatoriamente em grupos para o experimento. Os grupos experimentais A e B receberam treinamento de resistência com cargas diferentes, enquanto o grupo de controle recebeu apenas o treinamento aeróbico comum. Índices corporais como perimetria e IMC foram coletados antes e após da intervenção para análise estatística e discussão. Resultados: Após o experimento, o peso corporal do grupo experimental A alterou de 81,62±4,12 para 76,20±5,49, o IMC de 27,22±1,67 para 25,98±1,74, a circunferência da cintura de 89,11±5,62 para 87,27±6,34, circunferência do quadril de 101,61±5,43 para 98,45±5,62, relação cintura/quadril de 0,89±2,34 para 0,87±2,13, e relação de gordura corporal de 27,58±3,83 para 22,61±2,99. Também forma notadas alterações significativas nos dados do grupo experimental A após o treinamento de resistência com cargas distintas. Essas alterações foram similares às do grupo experimental B, porém as alterações nos dados do grupo controle não foram evidenciadas. Conclusão: O treinamento de resistência com cargas pode efetivamente ajudar aos estudantes universitários obesos a melhorarem a sua composição corporal e qualidade física. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

RESUMEN Introducción: La obesidad tiene un gran impacto negativo en los estudiantes universitarios, tanto en la salud física como mental. Se cree que el entrenamiento de resistencia, como ejercicio aeróbico promotor de hipertrofia muscular, puede promover un efecto reductor de la obesidad en esta clase de individuos. Objetivo: Verificar los efectos del entrenamiento de resistencia con cargas sobre el peso en estudiantes universitarios. Métodos: 120 estudiantes universitarios obesos voluntarios fueron divididos equitativa y aleatoriamente en grupos para el experimento. Los grupos experimentales A y B recibieron entrenamiento de resistencia con diferentes cargas, mientras que el grupo de control sólo recibió entrenamiento aeróbico regular. Se recogieron índices corporales como la perimetría y el IMC antes y después de la intervención para su análisis estadístico y discusión. Resultados: Tras el experimento, el peso corporal del grupo experimental A pasó de 81,62±4,12 a 76,20±5,49, el IMC de 27,22±1,67 a 25,98±1,74, la circunferencia de la cintura de 89,11±5,62 a 87, 27±6,34, el perímetro de la cadera de 101,61±5,43 a 98,45±5,62, el cociente cintura/cadera de 0,89±2,34 a 0,87±2,13, y el cociente de grasa corporal de 27,58±3,83 a 22,61±2,99. También se observaron cambios significativos en el grupo experimental A tras el entrenamiento de resistencia con diferentes cargas. Estas alteraciones fueron similares a las del grupo experimental B, sin embargo, no se evidenciaron alteraciones en los datos del grupo control. Conclusión: El entrenamiento de resistencia con cargas puede ayudar eficazmente a los estudiantes universitarios obesos a mejorar su composición corporal y su calidad física. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

Clinical research of Huashi-Xingyu-Qingre decoction combined with conventional western medicine therapy for the oral lichen planus / 国际中医中药杂志

Objective To investigate the clinical application of Huashi-Xingyu-Qingre decoction for the treatment of oral lichen planus (OLP).Methods According to the random table method,83 OLP patients were divided into control group (n=41) and the research group (n=42).The patients in the control group were treated with conventional medicine,while the patients in the research group were treated with Huashi-Xingyu-Qingre decoction on the basis of control group.Two groups of patients were treated for 6 weeks.The clinical total effective rate of two groups after treatment was counted.The serum haptoglobin,vitamin D binding protein,AT-Ⅲ,IL-6,IL-8,TNF-α and peripheral blood CD3+,CD4+,CD4+/CD8+ were determined respectively before and after treatment.The adverse reaction incidence and recurrence rate of two groups were observed.Results The total effective rate of research group was 92.9％ (39/42),while the total effective rate of control group was 63.4％ (26/41),and the difference between two groups was statistically significant (22=10.589,P=0.001).After treatment,the serum haptoglobin (6.11 ± 0.72 μg/ml vs.5.58 ± 0.69 μg/ml,t=3.423) of research group were significantly higher than the control group (P＜0.05),while the serum vitamin D binding protein (1.48 ± 0.25 μg/ml vs.2.06 ± 0.31 μg/ml,t=9.394),AT-Ⅲ,IL-6,1L-8,TNF-α of research group were significantly lower than the control group (t were 17.561,12.664,7.423,13.763,P＜0.01),and the peripheral blood CD3+,CD4+,CD4+/CD8+ of research group were significantly higher than the control group (t were 5.368,4.694,3.558,P＜0.01).The recurrence rate of control group was 30.8％ (8/26),which was significantly higher than the research group of 7.7％ (3/39) (x2=5.909,P=0.015).Conclusions The clinical curative effect of Huashi-Xingyu-Qingre decoction on the treatment for OLP is significantly,which can improve the patient's serum differential proteins and inflammatory cytokines,improve the body's immune function.It has the high security of the forward curative effect,which provides new thinking for clinical treatment of CFS.

Advance on targets and drugs for anti-HIV / 中国中药杂志

As the spreading of AIDS over the world, to research effective anti-HIV drugs is required. The review contains the process of discovering targets for anti-HIV especially entry/infuse, reverse transcriptase, protease and integrase, and describes the effective component of traditional Chinese drugs for these targets and the anti-HIV drugs being researched or used in clinic.

Immunogenicity of DNA and Recombinant Sendai Virus Vaccines Expressing the HIV-1 gag Gene / 中国病毒学·英文版

Combinations of DNA and recombinant-viral-vector based vaccines are promising AIDS vaccine methods because of their potential for inducing cellular immune responses. It was found that Gag-specific cytotoxic lymphocyte (CTL) responses were associated with lowering viremia in an untreated HIV-1 infected cohort. The main objectives of our studies were the construction of DNA and recombinant Sendal virus vector (rSeV) vaccines containing a gag gene from the prevalent Thailand subtype B strain in China and trying to use these vaccines for therapeutic and prophylactic vaccines. The candidate plasmid DNA vaccine pcDNA3.1(+)-gag and recombinant Sendai virus vaccine (rSeV-gag) were constructed separately. It was verified by Western blotting analysis that both DNA and rSeV-gag vaccines expressed the HIV-1 Gag protein correctly and efficiently. Balb/c mice were immunized with these two vaccines in different administration schemes. HIV-1 Gag-specific CTL responses and antibody levels were detected by intracellular cytokine staining assay and enzyme-linked immunosorbant assay (ELISA) respectively. Combined vaccines in a DNA prime/rSeV-gag boost vaccination regimen induced the strongest and most long-lasting Gag-specific CTL and antibody responses. It maintained relatively high levels even 9 weeks post immunization. This data indicated that the prime-boost regimen with DNA and rSeV-gag vaccines may offer promising HIV vaccine regimens.

Mobile network on telemedicine dynamic ECG monitoring system / 医疗卫生装备

Mobile network is used to transmit signals for telemedicine dynamic ECG monitoring system.In this way,ECG monitoring can be performed to patients at all times and places,thus really realizing telemedicine dynamic ECG monitoring.In the paper,the system is studied.The discussion on how to transmit ECG signals and feedback the diagnostic message through mobile network is presented in detail.