ABSTRACT
In 108 histopathologically proved breast cancer patients, after surgical treatment with modified radical mastectomy, two radiation dose schedules have been compared. Radiation therapy was given on a 60Co teletherapy machine using gent pair technique for chest wall irradiation and direct fields for lymphatic drainage areas. The patients were randomly divided into two groups (Group A and Group B). 54 patients were given external radiotherapy 40 Gy/17 F/3.2 weeks and remaining 54 patients were given 45 Gy/20 F/4 weeks. Results of treatment in Group A versus Group B were as follows; chest wall failure 5/50(10%) versus 3/54 (5.6%), axillary lymphnods failure 3/50(6%) versus 4/54(7%), distant metastasis 16/50(32%) versus 15/54(28%). Radiation reactions were almost similar in both the groups. Skin reactions were most common radiation effects [45/50 (90%) in Group A and 43/54 (79.6% in Group B]. Thus no statistically significant difference in local control and efficacy of these two radiation dose schedules was observed in postmastectomy carcinoma of the breast.
Subject(s)
Adult , Aged , Breast Neoplasms/diagnosis , Carcinoma/diagnosis , Dose-Response Relationship, Radiation , Female , Humans , Mastectomy/methods , Middle Aged , Prognosis , Radiation Dosage , Radiotherapy, Adjuvant , Survival Rate , Treatment OutcomeABSTRACT
Mean MDA level in the fifty women was 3.41 +/- 0.75 nmol/ml [table: see text]