ABSTRACT
Background: Large lymph-node is clinically common sign. However, in some cases, it is difficult to diagnosis by staining method routinely. Objectives: To classify of lymph node lesions by histopathological and immunohistochemical study. Subjects and methods: 1860 cases carried out lymph node biopsies at K Hospital were histologically and immunohistochemically analyzed. Results: The most common lesions were lymph node metastasis (35.25%) chronic lymphnoditis (20.82%), tuberculous lymphnoditis (19.42%) and non Hodgkin lymphoma (18.62%). Histological typing of metastasis revealed that the most frequent types were undifferentiated carcinomas (28.13%), squamous carcinomas (23.7%), adenocarcinomas (16.97%) and type-unspecified carcinomas (13.3%). Non Hodgkin lymphoma rate was higher than that of Hodgkin lymphoma (86.06% versus 12.8%). Immunopheotype of non Hodgkin lymphomas showed that 79.71 % were B cell type, 18.15% were T cell type and 2.14% were Ki-1 type. The most common types of B cell lymphomas were diffuse large B cell lymphomas (35.57%), follicular lymphomas (25.9%) and diffuse small B cell lymphomas (13.83%), The most common types of T cell lymphomas were lymphoblastic T cell lymphomas (41.8%)., large T cell lymphomas (23.53%) and unspecified periphery T cell lymphomas (11.76%). Conclusion: Immunohistochemical analysis of metastasis allowed identifying immunophenotypes of different types of metastatic carcinoma and melanoma and evaluating the origin of unknown primary metastasis. \r\n', u'\r\n', u'\r\n', u'
Subject(s)
Immunohistochemistry , Lymphadenitis , LymphomaABSTRACT
Background: Non-Hodgkin's lymphoma is a malignant (cancerous) growth of B or T white blood cells (lymphocytes) in the lymph system. Many lymphoma classifications were proposed. All were based by groups of the original cells, histopathological appearances and clinical features. Purpose: Histological classification of lymph node malignant non - \r\n", u'Hodgkin lymphoma based on the new WHO 2001 classification. Objectives: To apply new WHO 2001 classification of 165 cases of malignant non Hodgkin lymphoma were histopathologically and immunohisto chemically studied at K hospital in Hanoi. Subjects and method: The study included 165 patients with malignant non Hodgkin lymphoma were examined and treated at K hospital in Hanoi from 2000 to 2003. Results: The study based on new WHO 2001 classification of 165 cases of malignant non Hodgkin lymphoma showed results B lymphoma: Diffuse large B - cell lymphoma accounts for 63.3%, follicular lymphoma: 17.5%, small lymphocytic lymphoma: 12.5%, mantle cell lymphoma: 1.7% and the others are at low rate. T lymphoma: large T-cell lymphoma accounts for 35.0%, T lymphoblastic lymphoma: 30.0%, angioimmunoblastic T-cell lymphoma: 12.5%, peripheral T- cell lymphoma, unspecified: 10.0%, the others are at low rate. Conclusion: We concluded that new WHO classification of malignant non Hodgkin is reproducible in our practice and should be useful in the treatment decision. \r\n', u'
Subject(s)
LymphomaABSTRACT
The authors report a histological study of chronic gastritis. Results are as follows: Chronic gastritis showed high rate of chronic atrophic gastritis (76.1%), among them mild atrophic gastritis is 60%, moderate and severe atrophic gastritis is 15% and 1.1%, respectively. The majority of gastritis is in active chronic gastritis patterns (75%); H. pylori infection rate is 52.1%. Intestinal metaplasia was detected in 31.8%. The rate of complete intestinal metaplasia is higher than that of incomplete intestinal metaplasia (63.3% vs. 36.3%). Dysplasia was revealed in 7.9% (low grade: 77.3%; high grade: 22.7%. There is a significant correlation between atrophic levels and the rate of metaplasia and dysplasia.