Study on therapeutic results of adefovir dipivoxil in patients with HbeAg positive chronic hepatitis

Background: Hepatitis B is a potentially serious form of liver inflammation due to infection by the hepatitis B virus (HBV). It occurs in both rapidly developing (acute) and long-lasting (chronic) forms, and is one of the most common chronic infectious diseases worldwide. HBV infection is very common in Thua Thien \ufffd?Hue. Objectives:. Our study is aimed to assess the efficacy and safety of Adefovir dipivoxil(ADV) in patients with HBeAg positive chronic hepatitis B .. Subjects and method: Design of study: Prospective; 36 patients with HbeAg (+) chronic B hepatitis were enrolled in this study, all patients were treated with Adefovir dipivoxil in 24 months at Hue University Hospital from October 2004 to September 2006 . Results: The rate of normalization of ALAT is 50 % after 6 months, 66.66% after 12 months and 69.44% after 24 months. The rate of HbeAg seroconversion is 11.11 % after 12 months and 30.55% after 24 months. This rate is Significantly higher in group of patients having the activity of SePT between 5 - 10 normal (58.33%). The rate of phenotypic resistance is only 2.77% after 12 months and 8.33% after 24 months. The tolerance is generally good\r\n', u'even in long - term treatment and no complication of renal\r\n', u'insufficiency was found. Conclusion: ADV appears an effective and safe in patients with HBeAg(+) chronic hepatitis. \r\n', u'

Some biochemical disorders among patients with hepatocellular carcinoma

The biochemical changes among patients with hepatocellular carcinoma were various and common in which reduction of albumin synthesis (61%), reversion of A/G ratio (58%), bilirubinemia (21%), increases of SGOT (91%) and SGPT (82%) and these increases were direct proportional with progress of disease

Investigation of serum markers of hepatitis C virus in the hepatocellular carcinoma

100 patients with HCC, diagnosed by the clinical, Alpha Foetoprotein, imaging and cytological criteria; 50 patients in the control group. Anti HCV are performed by the techniques of EIA. HCV RNA is detected by RT PCR (reverse transcriptase PCR). The molecular biological techniques are performed at the Central Bio-medical laboratory in Hanoi Medical School. The frequency of serum anti HCV(ELISA) and especially of HCV RNA (RT-PCR) in the patients with HCC is also significantly higher than the one in the group of control: Anti HCV and HCV RNA.The co infection HBV-HCV is not significant in the hepatocarcinogennesis in our study. This study showed that hepatitis B virus is an important etiologic factor in the hepatocarinogenesis in Thua Thien Hue. The role of HCV is also remarkable and the co infections HCV-HBV are not significant in our study

Technique of amplification of gene chain by polymerase chain reaction in the treatment of the hepatitis C

This paper introduces the theoretical basis of the amplification of the polymerase chain reaction (PCR) in the diagnosis of hepatitis C and process of discovering the hepatitis C by PCR. This is a technique with the high sensitivity and very specificity and gives the results rapidly. However, the application of this technique requires many experiences and the deep knowledge for its limitation, especially contamination.

Hepatitis C virus and primary liver cancer

Beside of causative agents of hepatitis B virus, recent studies start discovering the causative agent of hepatitis C virus for etiology of primary liver cancer. This virus plays a very dangerously because of its potential clinical conditions as well as having no effective vaccine for active prevention. The Hepatitis C virus impacts by both indirect and direct mechanism. A synergic impact of Hepatitis C virus and alcoholism as well as Hepatitis B virus has been proved

Hepatitis B virus and primary liver cancer

Incidence of primitive liver cancer has the regularly increased in Asia as well as in Vietnam. Hepatitis B virus is proved as the most important causative factor by many epidemiological and molecular studies. In the pathogenesis, HBV acts via two mechanisms. The hepatitis B vaccination efforts, for all the new born babies and as well as for all the people HbsAg negative, is very necessary and urgent to reduce the incidence of PCL in the next decades

Investigating favorable factors and treatment responses in the patients with biliary ascariasis who admitted to Hue Central Hospital

Between 1990 to 1994, 217 patients were diagnosed with biliary ascariasis by ultrasonography. It was showed that biliary ascariasis is a pathological condition with excess incidence. Treatment in complicated or pregnant cases is difficult and costly. Some factors, especially female gender, pregnancy, and pH level of biliary fluid can influence favorably to the migration of ascarid. Ascarid infection density does not affect to the relapse frequency. Use helminthics early with single dose can provide the pain relief rapidly, reduce the rate of complication and avoid overuse the anti-spasmodics. The patients with history of biliary asariasis relapses should be followed-up and treated actively.

Causes and risk factors for upper digestive hemorrhage

Studying on 60 patients with upper digestive hemorrhage to determine the causes of disease showed that duodenal ulceration (26.7%), peptic ulceration (21.7%), gastritis (11.9%), and gastroduodenal ulceration (8.3%). Mallory - Weiss (8.3%), esophageal venous rupture (8.3%) peptic cancer (6.6%), pancreatic head cancer compressing the O2 duodenum (1.6%), datric polyps (1.6%) and unidentified cause (5%).

Hepatocellular carcinoma in HuÕ hospital during 1990-1995 and 2000

A study on patients with hepatocellular carcinoma in HuÕ hospital during 1990-1995 and 2000 has shown that the disease was increasingly during 1990-2000, the morbidity rate was predominant higher than this in women, and average age of patients was reduced. The major etiological agent was hepatitis B virus. The alcohol played a combined role with hepatitis B virus in the hepatocellular carcinoma. The role of hepatitis C virus was not statistical significant.

Comparative study on some features of 2 patient groups of hepatocellular carcinoma with possitive HBV DNA and HCV RNA

A study carried out on patients with hepatocellular carcinoma in Hue hospital during 2000-2001. The obtained results as following: the average age of patients with hepatocellular carcinoma with positive HBVDNA was lower than this of patients with the hepatocellular carcinoma with positive HCVRNA. While the rate of male/female among group of hepatocellular carcinoma with positive HBVDNA was higher than this among group of hepatocellular carcinoma with the positive HCVRNA. The clinical and biological symptoms and ultrasound related with the cirrhosis in the group of hepatocellular carcinoma with the positive HCVRNA were more frequent than these in the group of hepatocellular carcinoma with positive HBVDNA were. There was difference of survival rate in the end of the sixth month between 2 groups but there was no difference in the end of the ninth month.

Study on the functional disorder of coagulation in patients with cirrhosis

Objectives: Assess some disorder of hemostasis in the patient of cirrhosis; Estimate the correlation between these disorders and the Child-Pugh score. Methods: 30 patients of cirrhosis diagnosed upon the clinical, biological and imaging criteria, in the Department of HepatoGastroEnterology, Hue Central Hospital, from January to October 2000. Results and conclusion: The frequency of the disorder of hemostasis in the patients of cirrhosis is about 92%, the most frequent of these disorders is the prolongation of prothrombine time (83.3%). A diminution of fibrinogen concentration was found in 46.7% the cases. Significant prolongation of the time of Howell and Cephalin - Kaolin time are found respectively in 53.4% and 40%. Thrombocytopenia occurs in only 6.7%. Clinical manifestations don't reflex exactly the disorders of hemostasis, bleeding in the peritoneal cavity was found in 13.3%. There isn't any strict correlation between Child-Pugh score (CPS) and any of the hemostasis disorders. Apart from a medium correlation between CPS and prothrombin time (r=0.56, p0.05)

The review of the etiology and some clinical features of the chronic pancreatitis in Hue Central hospital

The main cause of the chronic pancreatitis were the chronic alcoholism (64%). The other etiology were hyperlipiderma (8%), malnutriation especially 16% patients had clinical biological and histogical evidences related protein malnutriation. The clinical condition were various: the abdominal pain were most common (92%). The position of pain, regardless the acute pain attack can help the diagnosis. The most comon complications were the disorder of glucose toleration (48%) and false cyst in the pancreas (32%), disorder of exocrine functions (24%) in long term studied group.