ABSTRACT
OBJECTIVE: The relationship was studied between expression of c-erbB-2 oncoprotein and topoisomerase II-alpha as proliferating marker in precancerous lesions and invasive squamous carcinomas of the uterine cervix. METHODS: Total 81 formalin-fixed, paraffin-embedded sections of low-grade intrasquamous lesion (22 cases), high-grade intraepithelial lesions (42 cases) and invasive squamous cell carcinomas (17 cases) in the uterine cervix were stained by immunohistochemistry for expression of the c-erbB-2 oncoprotein and topoisomerase II-alpha. RESULTS: The expression of c-erbB-2 oncoprotein and staining index (mean+/-S.D) of topoisomerase II-alpha were statistically significant between precancerous lesions and invasive carcinoma. The expression of c-erbB-2 oncoprotein has correlation with staining index (mean+/-S.D) of topoisomerase II-alpha. CONCLUSION: There results suggest that the expression of c-erbB-2 protein has relationship with progression of squamous lesions and topoisomerase II-alpha is an useful proliferating marker in the uterine cervix. And, the expression of c-erbB-2 protein has correlation with expression of topoisomerase II-alpha.
Subject(s)
Female , Carcinoma, Squamous Cell , Cervix Uteri , DNA Topoisomerases, Type I , DNA , Immunohistochemistry , Receptor, ErbB-2ABSTRACT
Uterine myomas are the most common benign tumor of the female genital organ. Uterine artery embolization is well reported of primary treatment of uterine myoma. A 29 year-old nulliparous woman was diagnosed as uterine myoma by ultrasonogram. We embolize both uterine artery after treatment with GnRH analog and then we experience a case of improvement of menorrhagia, with reduction in uterine myoma size. So we report that case with a brief review.
Subject(s)
Adult , Female , Humans , Genitalia , Gonadotropin-Releasing Hormone , Leiomyoma , Menorrhagia , Ultrasonography , Uterine Artery Embolization , Uterine ArteryABSTRACT
Uterine myomas are the most common benign tumor of the female genital organ. Uterine artery embolization is well reported of primary treatment of uterine myoma. A 29 year-old nulliparous woman was diagnosed as uterine myoma by ultrasonogram. We embolize both uterine artery after treatment with GnRH analog and then we experience a case of improvement of menorrhagia, with reduction in uterine myoma size. So we report that case with a brief review.
Subject(s)
Adult , Female , Humans , Genitalia , Gonadotropin-Releasing Hormone , Leiomyoma , Menorrhagia , Ultrasonography , Uterine Artery Embolization , Uterine ArteryABSTRACT
OBJECTIVE: Our purpose of study was to investigate whether in vivo levels of tumor necrosis factor-alpha in plasma and peritoneal fluid (PF) differ in women with and without endometriosis.Design : Prospective and case-control study. METHODS: Fifty-seven women with laparotomy or laparoscopic findings of minimal to severe endometriosis, and forty-two women with no visual evidence of pelvic endometriosis and with benign gynecologic disease. Tumor necrosis factor-alpha levels in plasma and PF were determined using commercial ELISA. Tumor necrosis factor-alpha concentrations were compared among women with and without endometriosis, and then also were compared according to the revised American Fertility Society classification. RESULTS: Tumor necrosis factor-alpha concentrations were not significantly increased in the plasma and PF of women with endometriosis than in matched normal controls. Tumor necrosis factor-alpha concentrations in endometriosis stage III and IV were sightly increased, which were not increased statistically significant. CONCLUSIONS: Plasma and PF tumor necrosis factor-alpha levels were not different between women with and without endometriosis. Our RESULTS: do not rule out the hypothesis that tumor necrosis factor-alpha may be involved in the pathogenesis of some features of endometriosis.