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Indian J Exp Biol ; 2004 Aug; 42(8): 787-91
Article in English | IMSEAR | ID: sea-61484

ABSTRACT

Effect of the aqueous leaf extract of I. gabonensis on the gastrointestinal tract was investigated on isolated rabbit jejunum, guinea pig ileum, gastrointestinal motility, castor oil-induced diarrhoea in mice and castor oil-induced fluid accumulation in rats. The results showed that the extract exhibited a concentration-dependent relaxation of spontaneous pendular movement of isolated rabbit jejunum and guinea pig ileum, and attenuated both acetylcholine-induced contraction of rabbit jejunum and histamine-induced contraction of guinea pig ileum. The extract (100, 200 and 400 mg/kg) also caused a significant dose-dependent decrease of gastrointestinal motility in mice (40.12, 39.45 and 37.45%), intestinal fluid accumulation in rats (71.43, 81.63 and 83.27%), and remarkably protected mice against castor oil-induced diarrhoea [58.33, 75 and 91.67% (Di Carlo score)] respectively. Preliminary phytochemical screening of the aqueous leaf extract of I. gabonensis revealed the presence of saponins, tannins, phenols and phlobatanins.


Subject(s)
Animals , Antidiarrheals/pharmacology , Cellulose/pharmacology , Diarrhea/drug therapy , Female , Gastrointestinal Motility/drug effects , Gastrointestinal Tract/drug effects , Guinea Pigs , Male , Mice , Phytotherapy , Plant Extracts/pharmacology , Rabbits , Rats , Rats, Wistar , Simaroubaceae
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