ABSTRACT
The current study aimed to evaluate the analgesic and anti-inflammatory effects of the ethanolic extract of roots of Hibiscus rosa sinensis [HRS]. The ethanolic extract was studied on tail flick test, acetic acid induced writhing test, tail immersion test, carrageenan induced paw edema test, formalin induced paw licking test and dextran induced paw edema test at different doses i.e. 250 mg/kg and 500 mg/kg. The oral administration of Hibiscus extract respectively has been shown significant [p<0.05] dose dependent analgesic [prolongation of the reaction time] and anti-inflammatory [inhibition of edema] effects at all the treated and standard groups when compared with the control group. These findings of analgesic and anti-inflammatory testing have revealed that root extract of this plant possesses remarkable analgesic and anti-inflammatory effects
ABSTRACT
Cytotoxic and antiviral activity of aqueous leaves extracts of three plants: Azadirachta indica, Moringa oleifera and Moms alba against Foot and Mouth disease virus [FMDV] were determined using MTT assay [3-[4, 5-Dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide]. Eight different concentrations of each plant were evaluated. Cytotoxic and antiviral activity of each extract was evaluated as cell survival percentage and results were expressed as Means +/- S.D. From the tested plant extracts, Azadirachta indica and Moringa oleifera exhibited cytotoxicity at 200 and 100 microg/ml respectively. In case of antiviral assay, Moringa oleifera showed potent antiviral activity [p<0.05] while Azadirachta indica showed significant antiviral activity in the range of 12.5-50 microg/ml and 50-100 microg/ml respectively. In contrast no anti-FMDV activity in the present study was observed with Morus alba, although all the tested concentrations were found to be safe