ABSTRACT
Background: A Colostomy is a revocable surgical procedure an incision in the anterior abdominal wall and suturing it into place in which a stoma is formed by drawing the healthy end of the large intestine or colon through. This opening, in conjunction with the attached stoma appliance, provides an alternative channel for feces to leave the body. Due to anatomical defects frequently referred for closure colostomy, colostomies are often used in cases of imperforate anus and other conditions. The neonatal & children who are unable to pass feces normally and safely. pediatrics colostomy. Some neonates require emergency surgery on their tummy in the first few months of life. It is most commonly due to being born prematurely and developing a bowel problem or a blockage of the bowel. As part of this surgery, the ends of the bowel may be brought to the skin surface to divert stool into a bag called a colostomy. Intended to be temporary with reversal, later on, the stoma allows time for the bowel to rest and recover. Aim of the study: To find out the outcome analysis of colostomy closure in different pediatric surgical conditions and were reviewed to look for complications following closure colostomy.Material & Methods:This prospective was conducted in the department of Pediatrics Surgery Bangladesh Shishu Hospital & Institute, Dhaka, and Lubana General Hospital & Cardiac Center, Dhaka, Bangladesh from July 2014 to June 2021. A total of 86 patients who underwent colostomy closure were enrolled in this prospective study as the study population. Data including age, gender, surgical conditions, complications of the patients and oral feeding, and bowel preparation were all collected from the patients’ parents or hospital admission files.Results:Out of 86 cases included the age range from 8 months-10 years. There were 37(43.0%) females and 49(57.0%) males and there were more difficulties with Anorectal malformation (43.02%) than with Hirschsprung disease (40.7%). There was no record of using Necrotizing Enterocolitis, in surgical patients. The risk of wound infection and leakage was greater than any other consequence in the patients. The illness known as colostomy was predominantly encountered in men. No morbidity was recorded in this study. Conclusions:Proper stoma care, the use of well-fitting colostomy bags, and early colostomy closure enhance the prognosis. Prior to surgery, encourage thorough mechanical bowel preparation and antibiotic use. The key to a successful colostomy closure for anti-surgical diseases is appropriate IV feeding after surgery.
ABSTRACT
Shilajit is a panacea in Ayurveda, the Indian traditional system of medicine. The major bioactives of shilajit have been identified as dibenzo-alpha-pyrones (DBPs), its oligomers and aminoacyl conjugated derivatives. These bioactive compounds play a crucial role in energy metabolism in all animal cells including those of man. 3-hydroxydibenzo-alpha-pyrone (3-OH-DBP), a key DBP component of shilajit is converted, among other products, to another active DBP derivative, viz. 3,8-hydroxydibenzo-alpha-pyrone, 3,8(OH)2-DBP, in vivo, when its precursor is ingested. 3,8(OH)2-DBP is then involved in energy synthesis in the mitochondria in the reduction and stabilization of coenzyme Q10 in the electron transport chain. As the chemical synthesis of 3,8(OH)2-DBP is a complex, multi-step process and economically not readily viable, we envisioned the development of a process using microorganisms for bioconversion of 3-OH-DBP to 3,8(OH)2-DBP. In this study, the biotransformation of 3-OH-DBP is achieved using Aspergillus niger, which was involved in the humification process on sedimentary rocks leading to shilajit formation. A 60 percent bioconversion of 3-OH-DBP to 3,8(OH)2-DBP and to its aminoacyl derivatives was achieved. The products were characterized and estimated by high performance liquid chromatography (HPLC), high performance flash chromatography (HPFC) and gas chromatography-mass spectrometry (GC-MS) analyses. Among the Aspergillus species isolated and identified from native shilajit, A. niger was found to be the most efficient for this bioconversion.