Preliminary investigation on the relation between clinical progress and anti-small monomolecular peptides antibody in individual infected with HIV / 中华实验和临床病毒学杂志

<p><b>OBJECTIVE</b>To study the quantity of anti-R7V in individuals infected with HIV and AIDS patients and its relation with the progression of disease.</p><p><b>METHODS</b>ELISA and precipitation and other methods were used to investigate the quantity of anti-R7V in asymptomatic long-term survivors and AIDS patients.</p><p><b>RESULTS</b>Positive rate and quantity of anti-R7V were higher in the HIV active ones and AIDS. It showed that the quantity and positive rate of anti-R7V were rather high in dissolving test.</p><p><b>CONCLUSIONS</b>It is strong suggestion for anti-R7V to obstruct the replication of virus by interfering the connection between HIV with CCR5 or CXCR4 and so it impossible HIV entering to CD4+ T cells.</p>